AIMC Topic: RNA Helicases

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Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N-methyladenosine recognition protein YTHDC2.

Nature communications Jan 6, 2026
YTHDC2, a unique YTH-domain-containing protein that recognizes N6-methyladenosine (mA) on RNA, plays critical roles in diverse pathological processes and represents a promising therapeutic target. Despite its potential, no potent small-molecule inhib...
Humans Drug Discovery Deep Learning RNA, Messenger RNA-Binding Proteins RNA Adenosine RNA Helicases
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Deep learning based analysis of G3BP1 protein expression to predict the prognosis of nasopharyngeal carcinoma.

PloS one Jan 27, 2025
BACKGROUND: Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) emerges as a pivotal oncogenic gene across various malignancies, notably including nasopharyngeal carcinoma (NPC). The use of automated image analysis tools for immunohistochem...
Humans Prognosis Female Adult Biomarkers, Tumor Male Middle Aged Deep Learning Gene Expression Regulation, Neoplastic DNA Helicases Immunohistochemistry Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms Poly-ADP-Ribose Binding Proteins RNA Recognition Motif Proteins RNA Helicases
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CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Journal of chemical information and modeling Jul 14, 2025
A critical assessment of computational hit-finding experiments (CACHE) challenge was conducted to predict ligands for the SARS-CoV-2 Nsp13 helicase RNA binding site, a highly conserved COVID-19 target. Twenty-three participating teams comprised of co...
Humans Machine Learning COVID-19 SARS-CoV-2 Molecular Docking Simulation Drug Discovery Antiviral Agents Protein Binding RNA, Viral Ligands COVID-19 Drug Treatment Methyltransferases Viral Nonstructural Proteins Binding Sites RNA Helicases
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