Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies i...
Deep learning models require large amounts of annotated data, which are hard to obtain in the medical field, as the annotation process is laborious and depends on expert knowledge. This data scarcity hinders a model's ability to generalise effectivel...
Biochemical and biophysical research communications
Jun 28, 2025
SARS-CoV-2 infection is highly contagious, prompting the World Health Organization to classify it as a global public health emergency. The virus has numerous potential hosts, which complicates efforts for effective prevention, diagnosis, and treatmen...
The papain-like protease (PLpro), a cysteine protease found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), plays a crucial role in viral replication by cleaving the viral polyproteins and interfering with the host's innate immune re...
Health policy (Amsterdam, Netherlands)
Jun 26, 2025
The SARS-COV2 pandemic has highlighted the urgent need for agile and responsive disease surveillance systems. To strengthen epidemiological surveillance and improve pandemic preparedness, policymakers must adopt real-time signal detection tools that ...
The global pandemic, due to the emergence of COVID-19, has created a public health crisis. It has a huge morbidity rate that was never comprehended in the recent decades. Despite numerous efforts, potent antiviral drugs are lacking. Repurposing of dr...
BACKGROUND: Numerous reviews have explored specific aspects of violence prevention apps, but given the rapid development of new apps, increased violence during COVID-19, and gaps in understanding functionalities and geographical distribution, an upda...
This systematic review aimed to explore the current applications, potential benefits, and issues of artificial intelligence (AI) in medical questionnaires, focusing on its role in 3 main functions: assessment, development, and prediction. The global ...
Recently, telemedicine has allowed doctor-to-patient or doctor-to-doctor consultations to tackle traditional problems: the COVID-19 pandemic, remote areas, long-time usage per visit, and dependence on family members in transportation. Nevertheless, f...
BACKGROUND: Incomplete Kawasaki disease (KD) is challenging to diagnose due to its lack of classic clinical features, yet it has a higher incidence of coronary artery lesions, making early detection crucial. Echocardiography plays a vital role in ide...
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