European journal of clinical pharmacology
Jan 3, 2026
BACKGROUND AND PURPOSE: There is a paucity of available clinical tools with which to accurately predict the risk of tigecycline-associated hypofibrinogenemia, an adverse reaction with a high incidence and serious consequences. This study aimed to dev...
BACKGROUND: Liver failure often results in significant coagulation dysfunction, which is a major complication. Artificial liver support systems (ALSS) have been used to ameliorate coagulation parameters, but the dynamic nature of these improvements a...
Biochemical and biophysical research communications
Oct 24, 2025
BACKGROUND: Aortic valve stenosis with coronary artery disease (AS-CAD) represents a common yet complex cardiovascular comorbidity, characterized by multifactorial pathogenesis and a lack of specific serum biomarkers. These limitations hinder early d...
Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies i...
European journal of trauma and emergency surgery : official publication of the European Trauma Society
May 23, 2025
BACKGROUND: Severe bleeding is a leading cause of ICU admission and mortality. Fibrinogen plays a crucial role in prognosis, yet optimal thresholds and supplementation targets remain unclear.
Regeneration of oral soft tissue defects, including mucogingival defects associated with the recession or loss of gingival and/or mucosal tissues around teeth and implants, is crucial for restoring oral tissue form, function, and health. This study p...
The Journal of thoracic and cardiovascular surgery
Nov 4, 2023
OBJECTIVES: The goal of this study was to improve decision making regarding the transfusion of patients at the end of extracorporeal circulation for cardiac surgery through machine learning predictions of the evolution of platelets counts, prothrombi...
The development of intelligent blood coagulation diagnoses is awaited to meet the current need for large clinical time-sensitive caseloads due to its efficient and automated diagnoses. Herein, a method is reported and validated to realize it through ...
BACKGROUND: Machine learning (ML) is a type of artificial intelligence (AI) and has been utilized in clinical research and practice to construct high-performing prediction models. Hidden blood loss (HBL) is prevalent during the perioperative period o...
OBJECTIVES: Circulating insulin concentrations mediate vascular-inflammatory and prothrombotic factors. However, it is unknown whether interindividual differences in circulating insulin levels are associated with different inflammatory and prothrombo...
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