UNLABELLED: In order to develop powerful computational predictors for identifying the biological features or attributes of DNAs, one of the most challenging problems is to find a suitable approach to effectively represent the DNA sequences. To facili...
DNA research : an international journal for rapid publication of reports on genes and genomes
Nov 27, 2014
The assembly of multiple genomes from mixed sequence reads is a bottleneck in metagenomic analysis. A single-genome assembly program (assembler) is not capable of resolving metagenome sequences, so assemblers designed specifically for metagenomics ha...
With the rapid development of genomic sequencing technologies, there is an increasing demand for efficient and accurate sequence analysis methods. However, existing methods face challenges in handling long, variable-length sequences and large-scale d...
MOTIVATION: Mobile genetic elements (MGEs) play an important role in facilitating the acquisition of antibiotic resistance genes (ARGs) within microbial communities, significantly impacting the evolution of antibiotic resistance. Understanding the me...
International journal of legal medicine
Sep 1, 2025
Forensic DNA analysis has transformed criminal investigations since its inception in 1985. Over four decades, this field has evolved through various phases-from the early stages of exploration to today's highly sophisticated methodologies. Key advanc...
The genome sequences of organisms form a large and complex landscape, presenting a significant challenge in bioinformatics: how to utilize mathematical tools to describe and analyze this space effectively. The ability to compare relationships between...
Nanopore sequencing allows identification of base modifications, such as methylation, directly from raw current data. Prevailing approaches, including deep learning (DL) methods, require training data covering all possible sequence contexts. These da...
BACKGROUND: The classification of DNA sequences is pivotal in bioinformatics, essentially for genetic information analysis. Traditional alignment-based tools tend to have slow speed and low recall. Machine learning methods learn implicit patterns fro...
Decoding DNA methylation sites through nanopore sequencing has emerged as a cutting-edge technology in the field of DNA methylation research, as it enables direct sequencing of native DNA molecules without the need for prior enzymatic or chemical tre...
MOTIVATION: Structural variants (SVs) play an important role in genetic research and precision medicine. As existing SV detection methods usually contain a substantial number of false positive calls, approaches to filter the detection results are nee...
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