AIMC Topic: Synthetic Biology

Clear Filters Showing 11 to 20 of 106 articles

Bringing neural networks to life.

Science (New York, N.Y.) Dec 12, 2024
A synthetic protein-based winner-take-all neural network controls cell fate decisions.
Humans Synthetic Biology Neural Networks, Computer Protein Interaction Maps
View on PubMed DOI

A synthetic protein-level neural network in mammalian cells.

Science (New York, N.Y.) Dec 12, 2024
Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de novo-designed protein heterodimers and engineered v...
Humans Viral Proteases Protein Engineering Synthetic Biology Protein Multimerization Neural Networks, Computer Proteolysis Protein Interaction Maps Recombinant Fusion Proteins Cell Death HEK293 Cells
View on PubMed DOI

BioTRY: A Comprehensive Knowledge Base for Titer, Rate, and Yield of Biosynthesis.

ACS synthetic biology Oct 18, 2024
Synthetic biology is rapidly evolving into a data-intensive science that increasingly relies on massive data sets; one of its applications is the evaluation of the economic viability of fermentation processes. However, the key economic indicators, na...
Databases, Factual Fermentation Synthetic Biology Computational Biology Knowledge Bases
View on PubMed DOI

Neonatal bioethics, AI, and genomics.

Early human development Oct 10, 2024
Artificial intelligence (AI) and synthetic biology will transform civilization. The only question is how. In this paper, I explore some recent developments in medical AI, genomics, and synthetic biology. I speculate about the implications of these te...
Neonatology Genomics Synthetic Biology Humans Artificial Intelligence Infant, Newborn Bioethics
View on PubMed DOI

Engineering Sequestration-Based Biomolecular Classifiers with Shared Resources.

ACS synthetic biology Sep 20, 2024
Constructing molecular classifiers that enable cells to recognize linear and nonlinear input patterns would expand the biocomputational capabilities of engineered cells, thereby unlocking their potential in diagnostics and therapeutic applications. W...
Sigma Factor Neural Networks, Computer DNA-Directed RNA Polymerases Synthetic Biology
View on PubMed DOI

Multicellular artificial neural network-type architectures demonstrate computational problem solving.

Nature chemical biology Sep 16, 2024
Here, we report a modular multicellular system created by mixing and matching discrete engineered bacterial cells. This system can be designed to solve multiple computational decision problems. The modular system is based on a set of engineered bacte...
Escherichia coli Synthetic Biology Problem Solving Neural Networks, Computer
View on PubMed DOI

SeqImprove: Machine-Learning-Assisted Curation of Genetic Circuit Sequence Information.

ACS synthetic biology Sep 4, 2024
The progress and utility of synthetic biology is currently hindered by the lengthy process of studying literature and replicating poorly documented work. Reconstruction of crucial design information through post hoc curation is highly noisy and error...
Machine Learning Synthetic Biology Data Curation Software Gene Regulatory Networks
View on PubMed DOI

Integrating Deep Learning and Synthetic Biology: A Co-Design Approach for Enhancing Gene Expression via N-Terminal Coding Sequences.

ACS synthetic biology Sep 4, 2024
N-terminal coding sequence (NCS) influences gene expression by impacting the translation initiation rate. The NCS optimization problem is to find an NCS that maximizes gene expression. The problem is important in genetic engineering. However, current...
Green Fluorescent Proteins Genetic Engineering Synthetic Biology Algorithms Deep Learning Bacillus subtilis Gene Expression
View on PubMed DOI

AI-Assisted Rational Design and Activity Prediction of Biological Elements for Optimizing Transcription-Factor-Based Biosensors.

Molecules (Basel, Switzerland) Jul 26, 2024
The rational design, activity prediction, and adaptive application of biological elements (bio-elements) are crucial research fields in synthetic biology. Currently, a major challenge in the field is efficiently designing desired bio-elements and acc...
Algorithms Synthetic Biology Deep Learning Artificial Intelligence Humans Biosensing Techniques Machine Learning Transcription Factors
View on PubMed DOI

Artificial Intelligence Methods and Models for Retro-Biosynthesis: A Scoping Review.

ACS synthetic biology Jul 24, 2024
Retrosynthesis aims to efficiently plan the synthesis of desirable chemicals by strategically breaking down molecules into readily available building block compounds. Having a long history in chemistry, retro-biosynthesis has also been used in the fi...
Artificial Intelligence Biocatalysis Biosynthetic Pathways Synthetic Biology
View on PubMed DOI
Popular Topics
Recent Journals