AIMC Topic: Synthetic Biology
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Machine learning for synthetic gene circuit engineering.
Current opinion in biotechnology
Jan 27, 2025
Synthetic biology leverages engineering principles to program biology with new functions for applications in medicine, energy, food, and the environment. A central aspect of synthetic biology is the creation of synthetic gene circuits - engineered bi...
AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks.
eLife
Jan 13, 2025
Many applications in biomedicine and synthetic bioengineering rely on understanding, mapping, predicting, and controlling the complex behavior of chemical and genetic networks. The emerging field of diverse intelligence investigates the problem-solvi...
Synthetic biology and artificial intelligence in crop improvement.
Plant communications
Dec 12, 2024
Synthetic biology plays a pivotal role in improving crop traits and increasing bioproduction through the use of engineering principles that purposefully modify plants through "design, build, test, and learn" cycles, ultimately resulting in improved b...
Bringing neural networks to life.
Science (New York, N.Y.)
Dec 12, 2024
A synthetic protein-based winner-take-all neural network controls cell fate decisions.
A synthetic protein-level neural network in mammalian cells.
Science (New York, N.Y.)
Dec 12, 2024
Artificial neural networks provide a powerful paradigm for nonbiological information processing. To understand whether similar principles could enable computation within living cells, we combined de novo-designed protein heterodimers and engineered v...
BioTRY: A Comprehensive Knowledge Base for Titer, Rate, and Yield of Biosynthesis.
ACS synthetic biology
Oct 18, 2024
Synthetic biology is rapidly evolving into a data-intensive science that increasingly relies on massive data sets; one of its applications is the evaluation of the economic viability of fermentation processes. However, the key economic indicators, na...
Neonatal bioethics, AI, and genomics.
Early human development
Oct 10, 2024
Artificial intelligence (AI) and synthetic biology will transform civilization. The only question is how. In this paper, I explore some recent developments in medical AI, genomics, and synthetic biology. I speculate about the implications of these te...
Engineering Sequestration-Based Biomolecular Classifiers with Shared Resources.
ACS synthetic biology
Sep 20, 2024
Constructing molecular classifiers that enable cells to recognize linear and nonlinear input patterns would expand the biocomputational capabilities of engineered cells, thereby unlocking their potential in diagnostics and therapeutic applications. W...
Multicellular artificial neural network-type architectures demonstrate computational problem solving.
Nature chemical biology
Sep 16, 2024
Here, we report a modular multicellular system created by mixing and matching discrete engineered bacterial cells. This system can be designed to solve multiple computational decision problems. The modular system is based on a set of engineered bacte...
SeqImprove: Machine-Learning-Assisted Curation of Genetic Circuit Sequence Information.
ACS synthetic biology
Sep 4, 2024
The progress and utility of synthetic biology is currently hindered by the lengthy process of studying literature and replicating poorly documented work. Reconstruction of crucial design information through post hoc curation is highly noisy and error...
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