Aquatic toxicology (Amsterdam, Netherlands)
Aug 1, 2025
Cell-based bioassays provide a dynamic and physiologically relevant platform for investigating cellular responses to chemical, biological, and environmental stimuli. Unlike traditional biochemical assays, cell-based bioassays utilize living cells to ...
Ecotoxicology and environmental safety
Jul 1, 2025
This study presents a comprehensive machine learning-driven analysis to understand and predict the toxicity of nanoparticles (NPs), a crucial aspect in ensuring the safe application of nanotechnology in medicine, pharmaceuticals, biotechnology, and v...
Environmental science & technology
Jun 10, 2025
The rising prevalence of nervous system disorders has become a significant global health challenge, with environmental pollutants identified as key contributors. However, the large number of environmental related compounds, combined with the low effi...
Trends in pharmacological sciences
Jun 1, 2025
Regulatory agencies require comprehensive toxicity testing for prenatal drug exposure, including new drugs in development, to reduce concerns about developmental toxicity, that is, drug-induced toxicity and adverse effects in pregnant women and fetus...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Developmental toxicity is key human health endpoint, especially relevant for safeguarding maternal and child well-being. It is an object of increasing attention from international regulatory bodies such as the US EPA (US Environmental Protection Agen...
Nucleic acids research
Jul 5, 2024
Interaction with chemicals, present in drugs, food, environments, and consumer goods, is an integral part of our everyday life. However, depending on the amount and duration, such interactions can also result in adverse effects. With the increase in ...
Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Jan 1, 2023
The progress of computational toxicology (CompTox) in drug safety research is highly anticipated. CompTox provides toxicity screening methods for drug discovery in the early stages. CompTox also contributes to fostering the application of the princip...
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Jan 1, 2020
Toxicity testing is critical for new drug and chemical development process. A clinical study, experimental animal models, and in vitro study are performed to evaluate the safety of a new drug. The limitations of these methods include extensive time f...
Toxicological sciences : an official journal of the Society of Toxicology
Aug 1, 2018
Animal-based methods for assessing chemical toxicity are struggling to meet testing demands. In silico approaches, including machine-learning methods, are promising alternatives. Recently, deep neural networks (DNNs) were evaluated and reported to ou...
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Jan 1, 2018
　Toxicity prediction based on stem cells and tissue derived from stem cells plays a very important role in the fields of biomedicine and pharmacology. Here we report on qRT-PCR data obtained by exposing 20 compounds to human embryonic stem (ES) cells...