When touching the surface of an object, its spatial structure translates into a vibration on the skin. The perceptual system evolved to translate this pattern into a representation that allows to distinguish between different materials. Here, we show...
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Jan 28, 2022
The purpose of this study was to compare a heuristic feature identification algorithm with output from the Beta Process Auto Regressive Hidden Markov Model (BP-AR-HMM) utilizing minimally sampled (≤ 100 Hz) human locomotion data for identification of...
This study applies adaptive mixture independent component analysis (AMICA) to learn a set of ICA models, each optimized by fitting a distributional model for each identified component process while maximizing component process independence within som...
Journal of computational biology : a journal of computational molecular cell biology
Jan 5, 2022
Non-negative matrix factorization (NMF) is a fundamental matrix decomposition technique that is used primarily for dimensionality reduction and is increasing in popularity in the biological domain. Although finding a unique NMF is generally not possi...
Identification of cell phenotypic states within heterogeneous populations, along with elucidation of their switching dynamics, is a central challenge in modern biology. Conventional single-cell analysis methods typically provide only indirect, static...
The ability to experience, use and eventually control anger is crucial to maintain well-being and build healthy relationships. Despite its relevance, the neural mechanisms behind individual differences in experiencing and controlling anger are poorly...
Large and densely sampled sensor datasets can contain a range of complex stochastic structures that are difficult to accommodate in conventional linear models. This can confound attempts to build a more complete picture of an animal's behavior by agg...
BACKGROUND: Mutation processes leave different signatures in genes. For single-base substitutions, previous studies have suggested that mutation signatures are not only reflected in mutation bases but also in neighboring bases. However, because of th...
BMC medical informatics and decision making
Dec 8, 2021
BACKGROUND: Alzheimer's disease (AD) is a highly heterogeneous disease with diverse trajectories and outcomes observed in clinical populations. Understanding this heterogeneity can enable better treatment, prognosis and disease management. Studies to...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2021
The identification of cancer subtypes is of great importance for understanding the heterogeneity of tumors and providing patients with more accurate diagnoses and treatments. However, it is still a challenge to effectively integrate multiple omics da...
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