BACKGROUND: Individual case review of spontaneous adverse event (AE) reports remains a cornerstone of medical product safety surveillance for industry and regulators. Previously we developed the Vaccine Adverse Event Text Miner (VaeTM) to offer autom...
With the rapid advancement of artificial intelligence (AI) and machine learning (ML) technologies, their applications in the medical field have expanded significantly. Particularly in vaccine innovation, AI and ML have shown considerable potential. T...
BACKGROUND: Vaccines are crucial for preventing infectious diseases; however, they may also be associated with adverse events (AEs). Conventional analysis of vaccine AEs relies on manual review and assignment of AEs to terms in terminology or ontolog...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2023
Vaccine development is a complex and long process. It involves several steps, including computational studies, experimental analyses, animal model system studies, and clinical trials. This process can be accelerated by using in silico antigen screeni...
Combinatorial chemistry & high throughput screening
Jan 1, 2023
One of the most dynamic approaches in biotechnology is reverse vaccinology, which plays a huge role in today's developing vaccines. It has the capability of exploring and identifying the most potent vaccine candidate in a limited period of time. The ...
Studies in health technology and informatics
Jun 29, 2022
In previous work, we implemented a deep learning model with CamemBERT and PyTorch, and built a microservices architecture using the TorchServe serving library. Without TorchServe, inference time was three times faster when the model was loaded once i...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Often likened to "the new electricity," artificial intelligence (AI) has broad and sweeping impact in many areas. Perhaps most exciting among these are in bioinformatics as AI allows for new and increasingly powerful ways of understanding genomics, p...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
Reverse vaccinology (RV) is the state-of-the-art vaccine development strategy that starts with predicting vaccine antigens by bioinformatics analysis of the whole genome of a pathogen of interest. Vaxign is the first web-based RV vaccine prediction m...
Vaccination is one of the most significant inventions in medicine. Reverse vaccinology (RV) is a state-of-the-art technique to predict vaccine candidates from pathogen's genome(s). To promote vaccine development, we updated Vaxign2, the first web-bas...
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