Uncovering key markers and therapeutic targets for renal fibrosis in diabetic kidney disease through bulk and single-cell RNA sequencing.

Journal: Journal of translational medicine
Published Date: Jul 4, 2025

Abstract

BACKGROUND: Diabetic kidney disease (DKD) is the major cause of chronic kidney failure, with tubulointerstitial fibrosis playing a crucial role in disease development. Identifying fibrosis-related genes is crucial for improving diagnosis and developing novel therapies due to the necessity for early detection and effective treatments.

Authors

  • Lijuan Li
  • Mi Tao
    Department of Nephrology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, China.
  • Xueyun Gao
    Department of Nephrology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, China.
  • Quan Cao
    Department of Nephrology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, China.
  • Zejing Liao
    Department of Nephrology, The First People's Hospital of Changde, Hunan, China.
  • Feng Chen
    Department of Integrated Care Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ayinigaer Yusufu
    Department of Nephrology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, China.
  • Haihang Nie
    Wuhan University Zhongnan Hospital, Wuhan, China.
  • Ziyue Zeng
    Department of Cardiology, Zhongnan Hospital, Wuhan University, Wuhan, China.
  • Kai Huang
  • Xuan Deng
    Department of Nephrology, Zhongnan Hospital, Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan, 430071, China. 761237742@qq.com.
  • Ping Gao
    Affiliated Hospital of North China University of Science and Technology, Tangshan, 063009, China.
  • Xiaoyan Wu
    Department of Cardiology, Lishui Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China.

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