AI Medical Compendium Journal:
BMC bioinformatics

Showing 91 to 100 of 772 articles

Classifying breast cancer subtypes on multi-omics data via sparse canonical correlation analysis and deep learning.

BMC bioinformatics
BACKGROUND: Classifying breast cancer subtypes is crucial for clinical diagnosis and treatment. However, the early symptoms of breast cancer may not be apparent. Rapid advances in high-throughput sequencing technology have led to generating large num...

Using protein language models for protein interaction hot spot prediction with limited data.

BMC bioinformatics
BACKGROUND: Protein language models, inspired by the success of large language models in deciphering human language, have emerged as powerful tools for unraveling the intricate code of life inscribed within protein sequences. They have gained signifi...

Predicting lncRNA-protein interactions through deep learning framework employing multiple features and random forest algorithm.

BMC bioinformatics
RNA-protein interaction (RPI) is crucial to the life processes of diverse organisms. Various researchers have identified RPI through long-term and high-cost biological experiments. Although numerous machine learning and deep learning-based methods fo...

xCAPT5: protein-protein interaction prediction using deep and wide multi-kernel pooling convolutional neural networks with protein language model.

BMC bioinformatics
BACKGROUND: Predicting protein-protein interactions (PPIs) from sequence data is a key challenge in computational biology. While various computational methods have beenĀ proposed, the utilization of sequence embeddings from protein language models, wh...

Deep self-supervised machine learning algorithms with a novel feature elimination and selection approaches for blood test-based multi-dimensional health risks classification.

BMC bioinformatics
BACKGROUND: Blood test is extensively performed for screening, diagnoses and surveillance purposes. Although it is possible to automatically evaluate the raw blood test data with the advanced deep self-supervised machine learning approaches, it has n...

An uncertainty-based interpretable deep learning framework for predicting breast cancer outcome.

BMC bioinformatics
BACKGROUND: Predicting outcome of breast cancer is important for selecting appropriate treatments and prolonging the survival periods of patients. Recently, different deep learning-based methods have been carefully designed for cancer outcome predict...

HormoNet: a deep learning approach for hormone-drug interaction prediction.

BMC bioinformatics
Several experimental evidences have shown that the human endogenous hormones can interact with drugs in many ways and affect drug efficacy. The hormone drug interactions (HDI) are essential for drug treatment and precision medicine; therefore, it is ...

GPAD: a natural language processing-based application to extract the gene-disease association discovery information from OMIM.

BMC bioinformatics
BACKGROUND: Thousands of genes have been associated with different Mendelian conditions. One of the valuable sources to track these gene-disease associations (GDAs) is the Online Mendelian Inheritance in Man (OMIM) database. However, most of the info...

Interpretable deep learning methods for multiview learning.

BMC bioinformatics
BACKGROUND: Technological advances have enabled the generation of unique and complementary types of data or views (e.g. genomics, proteomics, metabolomics) and opened up a new era in multiview learning research with the potential to lead to new biome...

Enabling personalised disease diagnosis by combining a patient's time-specific gene expression profile with a biomedical knowledge base.

BMC bioinformatics
BACKGROUND: Recent developments in the domain of biomedical knowledge bases (KBs) open up new ways to exploit biomedical knowledge that is available in the form of KBs. Significant work has been done in the direction of biomedical KB creation and KB ...