Expert opinion on drug metabolism & toxicology
May 13, 2025
BACKGROUND: Tegoprazan (LXI-15028), a novel potassium-competitive acid blocker, has shown great efficacy in treating acid-related disorders. However, its metabolic and excretion characteristics are not fully understood.
Expert opinion on drug metabolism & toxicology
May 11, 2025
INTRODUCTION: Healthcare professionals face increasing challenges when managing older patients, a group characterized by significant interindividual variability in comorbidity patterns, homeostatic capacity, frailty status, cognitive function, and li...
Expert opinion on drug metabolism & toxicology
Feb 2, 2025
INTRODUCTION: Drug-induced liver injury (DILI) is a leading cause of acute liver failure. Hepatotoxicity typically occurs only in a subset of individuals after prolonged exposure and constitutes a major risk factor for the termination of drug develop...
Expert opinion on drug metabolism & toxicology
Jul 10, 2024
BACKGROUND: Cardiotoxicity is a major cause of drug withdrawal. The hERG channel, regulating ion flow, is pivotal for heart and nervous system function. Its blockade is a concern in drug development. Predicting hERG blockade is essential for identify...
Expert opinion on drug metabolism & toxicology
May 27, 2024
INTRODUCTION: This review explores the transformative impact of machine learning (ML) on carcinogenicity prediction within drug development. It discusses the historical context and recent advancements, emphasizing the significance of ML methodologies...
Expert opinion on drug metabolism & toxicology
Mar 20, 2024
INTRODUCTION: Pharmacokinetic parameters assessment is a critical aspect of drug discovery and development, yet challenges persist due to limited training data. Despite advancements in machine learning and in-silico predictions, scarcity of data hamp...
Expert opinion on drug metabolism & toxicology
Dec 29, 2023
INTRODUCTION: The application of Artificial Intelligence (AI) to predictive toxicology is rapidly increasing, particularly aiming to develop non-testing methods that effectively address ethical concerns and reduce economic costs. In this context, Dev...
Expert opinion on drug metabolism & toxicology
Oct 27, 2023
INTRODUCTION: Although significant development has been made in high-throughput screening of oral drug absorption and oral bioavailability, prediction continues to play an important role in prediction of oral bioavailability and assisting in the pro...
Expert opinion on drug metabolism & toxicology
Jul 17, 2023
INTRODUCTION: Acute poisoning is a significant global health burden, and the causative agent is often unclear. The primary aim of this pilot study was to develop a deep learning algorithm that predicts the most probable agent a poisoned patient was e...