International journal of biological macromolecules
Apr 30, 2024
GRK5 holds a pivotal role in cellular signaling pathways, with its overexpression in cardiomyocytes, neuronal cells, and tumor cells strongly associated with various chronic degenerative diseases, which highlights the urgent need for potential inhibi...
International journal of biological macromolecules
Mar 27, 2024
Phosphorylation modifications play important regulatory roles in most biological processes. However, the functional assignment for the vast majority of the identified phosphosites remains a major challenge. Here, we provide a deep learning framework ...
International journal of biological macromolecules
Mar 20, 2024
Preserving fish meat poses a significant challenge due to its high protein and low fat content. This study introduces a novel approach that utilizes a common type of lanthanide metal-organic frameworks (Ln-MOFs), EuMOFs, in combination with 5-fluores...
International journal of biological macromolecules
Mar 7, 2024
The rational modification of siRNA molecules is crucial for ensuring their drug-like properties. Machine learning-based prediction of chemically modified siRNA (cm-siRNA) efficiency can significantly optimize the design process of siRNA chemical modi...
International journal of biological macromolecules
Feb 15, 2024
Magnesium ions (Mg) are essential for the folding, functional expression, and structural stability of RNA molecules. However, predicting Mg-binding sites in RNA molecules based solely on RNA structures is still challenging. The molecular surface, cha...
International journal of biological macromolecules
Feb 15, 2024
To develop ecofriendly multifunctional gel materials for sustainable flexible electronic devices, composite organohydrogels of gellan gum (GG) and polypyrrole (PPy) with an interpenetrating network structure (IPN-GG/PPy organohydrogels) were develope...
International journal of biological macromolecules
Feb 8, 2024
The prevalence of metabolic diseases is increasing at a frightening rate year by year. The burgeoning development of deep learning enables drug design to be more efficient, selective, and structurally novel. The critical relevance of Histone deacetyl...
International journal of biological macromolecules
Dec 13, 2023
Heat shock proteins (HSPs) are crucial cellular stress proteins that react to environmental cues, ensuring the preservation of cellular functions. They also play pivotal roles in orchestrating the immune response and participating in processes associ...
International journal of biological macromolecules
Nov 4, 2023
Aptamers are increasingly recognized as potent alternatives to antibodies for diagnostic and therapeutic applications. The application of deep learning, particularly attention-based models, for aptamer (DNA/RNA) sequences is an innovative field. The ...
International journal of biological macromolecules
Oct 30, 2023
In the present study, a new application was proposed for the eucalyptus sawdust waste, which is an environmental passive. Three adsorbent materials composed of chitosan (CS), sawdust (CSW), and magnetic beads (CSWF) were developed and used for the Di...