AIMC Journal:
International journal of molecular sciences

Showing 181 to 190 of 423 articles

Advancements in Drug Repurposing: Examples in Psychiatric Medications.

International journal of molecular sciences Jul 1, 2023
Because there are a limited number of animal models for psychiatric diseases that can be extrapolated to humans, drug repurposing has been actively pursued. This study was aimed at uncovering recent trends in drug repurposing approaches and new techn...
Humans Animals Drug Repositioning Mental Disorders Artificial Intelligence
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Deep Learning Approaches for lncRNA-Mediated Mechanisms: A Comprehensive Review of Recent Developments.

International journal of molecular sciences Jun 18, 2023
This review paper provides an extensive analysis of the rapidly evolving convergence of deep learning and long non-coding RNAs (lncRNAs). Considering the recent advancements in deep learning and the increasing recognition of lncRNAs as crucial compon...
Deep Learning Computational Biology RNA, Long Noncoding
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Bioengineered Enzymes and Precision Fermentation in the Food Industry.

International journal of molecular sciences Jun 15, 2023
Enzymes have been used in the food processing industry for many years. However, the use of native enzymes is not conducive to high activity, efficiency, range of substrates, and adaptability to harsh food processing conditions. The advent of enzyme e...
Fermentation Food Handling Artificial Intelligence Biomedical Engineering Enzymes Food-Processing Industry
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Is There a Role for Machine Learning in Liquid Biopsy for Brain Tumors? A Systematic Review.

International journal of molecular sciences Jun 3, 2023
The paucity of studies available in the literature on brain tumors demonstrates that liquid biopsy (LB) is not currently applied for central nervous system (CNS) cancers. The purpose of this systematic review focused on the application of machine lea...
Liquid Biopsy Meta-Analysis as Topic Artificial Intelligence Brain Neoplasms Machine Learning Humans
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An Unsupervised Classification Algorithm for Heterogeneous Cryo-EM Projection Images Based on Autoencoders.

International journal of molecular sciences May 6, 2023
Heterogeneous three-dimensional (3D) reconstruction in single-particle cryo-electron microscopy (cryo-EM) is an important but very challenging technique for recovering the conformational heterogeneity of flexible biological macromolecules such as pro...
Cryoelectron Microscopy Image Processing, Computer-Assisted Single Molecule Imaging Cluster Analysis Neural Networks, Computer Algorithms
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AI-Driven De Novo Design and Molecular Modeling for Discovery of Small-Molecule Compounds as Potential Drug Candidates Targeting SARS-CoV-2 Main Protease.

International journal of molecular sciences Apr 29, 2023
Over the past three years, significant progress has been made in the development of novel promising drug candidates against COVID-19. However, SARS-CoV-2 mutations resulting in the emergence of new viral strains that can be resistant to the drugs use...
Coronavirus 3C Proteases Models, Molecular Artificial Intelligence Small Molecule Libraries Neural Networks, Computer Drug Discovery COVID-19 Drug Treatment
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Identification of Protein Complexes by Integrating Protein Abundance and Interaction Features Using a Deep Learning Strategy.

International journal of molecular sciences Apr 26, 2023
Many essential cellular functions are carried out by multi-protein complexes that can be characterized by their protein-protein interactions. The interactions between protein subunits are critically dependent on the strengths of their interactions an...
Machine Learning Protein Subunits Deep Learning Mass Spectrometry Proteomics
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Detecting Pre-Analytically Delayed Blood Samples for Laboratory Diagnostics Using Raman Spectroscopy.

International journal of molecular sciences Apr 25, 2023
In this proof-of-principle study, we systematically studied the potential of Raman spectroscopy for detecting pre-analytical delays in blood serum samples. Spectra from 330 samples from a liver cirrhosis cohort were acquired over the course of eight ...
Liver Cirrhosis Spectrum Analysis, Raman Humans Neural Networks, Computer
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Targeting Protein-Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches.

International journal of molecular sciences Apr 25, 2023
Protein-protein interfaces play fundamental roles in the molecular mechanisms underlying pathophysiological pathways and are important targets for the design of compounds of therapeutic interest. However, the identification of binding sites on protei...
Artificial Intelligence Protein Binding Peptides Peptide Library Binding Sites Membrane Proteins
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From Deep Mutational Mapping of Allosteric Protein Landscapes to Deep Learning of Allostery and Hidden Allosteric Sites: Zooming in on "Allosteric Intersection" of Biochemical and Big Data Approaches.

International journal of molecular sciences Apr 24, 2023
The recent advances in artificial intelligence (AI) and machine learning have driven the design of new expert systems and automated workflows that are able to model complex chemical and biological phenomena. In recent years, machine learning approach...
Allosteric Site Deep Learning Artificial Intelligence Proteins Big Data
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