Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Insects rely on olfaction in many aspects of their life, and odorant receptors are key proteins in this process. Whereas a plethora of insect odorant receptor sequences is available, most of them are still orphan or uncompletely characterized, since ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
A classical problem in neuroscience, biology, and chemistry is linking the chemical structure of odorants to their olfactory perception. This difficulty arises from the subjective nature of odor perception, incomplete understanding of the physiologic...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Fluorescence microscopy is a key method for the visualization of cellular, subcellular, and molecular live-cell dynamics, enabling access to novel insights into mechanisms of health and disease. However, effects like phototoxicity, the fugitive natur...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
A significantly low success rate of human clinical studies has long been attributed to a capability gap, namely, an ineffective translation of the animal data to the human context. To bridge this capability gap, several correcting measures have been ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Artificial intelligence (AI) and machine learning (ML) have advanced in several areas and fields of life; however, its progress in the field of genomics is not matching the levels others have achieved. Challenges include but are not limited to the ha...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Despite unprecedented achievements, the domain-specific application of artificial intelligence (AI) in the realm of infection biology was still in its infancy just a couple of years ago. This is largely attributable to the proneness of the infection ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
SNARE proteins play a pivotal role in membrane fusion and various cellular processes. Accurate identification of SNARE proteins is crucial for elucidating their functions in both health and disease contexts. This chapter presents a novel approach emp...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
The interactions between long noncoding RNA (lncRNA) and protein play crucial roles in various biological processes. Computational methods are essential for predicting lncRNA-protein interactions and deciphering their mechanisms. In this chapter, we ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Single-cell omics technologies have revolutionized the study of long non-coding RNAs (lncRNAs), offering unprecedented resolution in elucidating their expression dynamics, cell-type specificity, and associated gene regulatory networks (GRNs). Concurr...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Protein structure prediction is fundamental to molecular biology and has numerous applications in areas such as drug discovery and protein engineering. Machine learning techniques have greatly advanced protein 3D modeling in recent years, particularl...