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Electrophysiology

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Third-order nanocircuit elements for neuromorphic engineering.

Nature
Current hardware approaches to biomimetic or neuromorphic artificial intelligence rely on elaborate transistor circuits to simulate biological functions. However, these can instead be more faithfully emulated by higher-order circuit elements that nat...

Recovery of reward function in problematic substance users using a combination of robotics, electrophysiology, and TMS.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology
BACKGROUND: Theoretical and empirical work suggest that addictive drugs potentiate dopaminergic reinforcement learning signals and disrupt the reward function of its neural targets, including the anterior midcingulate cortex (aMCC) and the basal gang...

Automatic deep learning-driven label-free image-guided patch clamp system.

Nature communications
Patch clamp recording of neurons is a labor-intensive and time-consuming procedure. Here, we demonstrate a tool that fully automatically performs electrophysiological recordings in label-free tissue slices. The automation covers the detection of cell...

A meta-analysis on the effectiveness of anthropomorphism in human-robot interaction.

Science robotics
The application of anthropomorphic design features is widely assumed to facilitate human-robot interaction (HRI). However, a considerable number of study results point in the opposite direction. There is currently no comprehensive common ground on th...

Manifold learning analysis suggests strategies to align single-cell multimodal data of neuronal electrophysiology and transcriptomics.

Communications biology
Recent single-cell multimodal data reveal multi-scale characteristics of single cells, such as transcriptomics, morphology, and electrophysiology. However, integrating and analyzing such multimodal data to deeper understand functional genomics and ge...

Large-scale electrophysiology and deep learning reveal distorted neural signal dynamics after hearing loss.

eLife
Listeners with hearing loss often struggle to understand speech in noise, even with a hearing aid. To better understand the auditory processing deficits that underlie this problem, we made large-scale brain recordings from gerbils, a common animal mo...

Learnable latent embeddings for joint behavioural and neural analysis.

Nature
Mapping behavioural actions to neural activity is a fundamental goal of neuroscience. As our ability to record large neural and behavioural data increases, there is growing interest in modelling neural dynamics during adaptive behaviours to probe neu...

Combining Machine Learning and Electrophysiology for Insect Odorant Receptor Studies.

Methods in molecular biology (Clifton, N.J.)
Insects rely on olfaction in many aspects of their life, and odorant receptors are key proteins in this process. Whereas a plethora of insect odorant receptor sequences is available, most of them are still orphan or uncompletely characterized, since ...

Intelligent in-cell electrophysiology: Reconstructing intracellular action potentials using a physics-informed deep learning model trained on nanoelectrode array recordings.

Nature communications
Intracellular electrophysiology is essential in neuroscience, cardiology, and pharmacology for studying cells' electrical properties. Traditional methods like patch-clamp are precise but low-throughput and invasive. Nanoelectrode Arrays (NEAs) offer ...