AI Medical Compendium Journal:
PLoS computational biology

Showing 111 to 120 of 484 articles

End-to-end deep learning approach to mouse behavior classification from cortex-wide calcium imaging.

PLoS computational biology
Deep learning is a powerful tool for neural decoding, broadly applied to systems neuroscience and clinical studies. Interpretable and transparent models that can explain neural decoding for intended behaviors are crucial to identifying essential feat...

AI-Aristotle: A physics-informed framework for systems biology gray-box identification.

PLoS computational biology
Discovering mathematical equations that govern physical and biological systems from observed data is a fundamental challenge in scientific research. We present a new physics-informed framework for parameter estimation and missing physics identificati...

Unsupervised learning of perceptual feature combinations.

PLoS computational biology
In many situations it is behaviorally relevant for an animal to respond to co-occurrences of perceptual, possibly polymodal features, while these features alone may have no importance. Thus, it is crucial for animals to learn such feature combination...

Inference of annealed protein fitness landscapes with AnnealDCA.

PLoS computational biology
The design of proteins with specific tasks is a major challenge in molecular biology with important diagnostic and therapeutic applications. High-throughput screening methods have been developed to systematically evaluate protein activity, but only a...

CyVerse: Cyberinfrastructure for open science.

PLoS computational biology
CyVerse, the largest publicly-funded open-source research cyberinfrastructure for life sciences, has played a crucial role in advancing data-driven research since the 2010s. As the technology landscape evolved with the emergence of cloud computing pl...

A neural network model for the evolution of learning in changing environments.

PLoS computational biology
Learning from past experience is an important adaptation and theoretical models may help to understand its evolution. Many of the existing models study simple phenotypes and do not consider the mechanisms underlying learning while the more complex ne...

PandoGen: Generating complete instances of future SARS-CoV-2 sequences using Deep Learning.

PLoS computational biology
One of the challenges in a viral pandemic is the emergence of novel variants with different phenotypical characteristics. An ability to forecast future viral individuals at the sequence level enables advance preparation by characterizing the sequence...

Joint representation of molecular networks from multiple species improves gene classification.

PLoS computational biology
Network-based machine learning (ML) has the potential for predicting novel genes associated with nearly any health and disease context. However, this approach often uses network information from only the single species under consideration even though...

Harnessing the flexibility of neural networks to predict dynamic theoretical parameters underlying human choice behavior.

PLoS computational biology
Reinforcement learning (RL) models are used extensively to study human behavior. These rely on normative models of behavior and stress interpretability over predictive capabilities. More recently, neural network models have emerged as a descriptive m...

Ten quick tips for fuzzy logic modeling of biomedical systems.

PLoS computational biology
Fuzzy logic is useful tool to describe and represent biological or medical scenarios, where often states and outcomes are not only completely true or completely false, but rather partially true or partially false. Despite its usefulness and spread, f...