AI Medical Compendium Journal:
Science China. Life sciences

Showing 1 to 10 of 14 articles

Predicting Lactobacillus delbrueckii subsp. bulgaricus-Streptococcus thermophilus interactions based on a highly accurate semi-supervised learning method.

Science China. Life sciences
Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) and Streptococcus thermophilus (S. thermophilus) are commonly used starters in milk fermentation. Fermentation experiments revealed that L. bulgaricus-S. thermophilus interactions (LbStI) su...

Graph based recurrent network for context specific synthetic lethality prediction.

Science China. Life sciences
The concept of synthetic lethality (SL) has been successfully used for targeted therapies. To further explore SL for cancer therapy, identifying more SL interactions with therapeutic potential are essential. Recently, graph neural network-based deep ...

Machine learning-aided scoring of synthesis difficulties for designer chromosomes.

Science China. Life sciences
Designer chromosomes are artificially synthesized chromosomes. Nowadays, these chromosomes have numerous applications ranging from medical research to the development of biofuels. However, some chromosome fragments can interfere with the chemical syn...

Enabling technology and core theory of synthetic biology.

Science China. Life sciences
Synthetic biology provides a new paradigm for life science research ("build to learn") and opens the future journey of biotechnology ("build to use"). Here, we discuss advances of various principles and technologies in the mainstream of the enabling ...

Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches.

Science China. Life sciences
Artificial intelligence (AI) models usually require large amounts of high-quality training data, which is in striking contrast to the situation of small and biased data faced by current drug discovery pipelines. The concept of federated learning has ...