AIMC Topic: Algorithms

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A novel deep machine learning algorithm with dimensionality and size reduction approaches for feature elimination: thyroid cancer diagnoses with randomly missing data.

Briefings in bioinformatics
Thyroid cancer incidences endure to increase even though a large number of inspection tools have been developed recently. Since there is no standard and certain procedure to follow for the thyroid cancer diagnoses, clinicians require conducting vario...

Exploring functional conservation in silico: a new machine learning approach to RNA-editing.

Briefings in bioinformatics
Around 50 years ago, molecular biology opened the path to understand changes in forms, adaptations, complexity, or the basis of human diseases through myriads of reports on gene birth, gene duplication, gene expression regulation, and splicing regula...

GEMF: a novel geometry-enhanced mid-fusion network for PLA prediction.

Briefings in bioinformatics
Accurate prediction of protein-ligand binding affinity (PLA) is important for drug discovery. Recent advances in applying graph neural networks have shown great potential for PLA prediction. However, existing methods usually neglect the geometric inf...

ctGAN: combined transformation of gene expression and survival data with generative adversarial network.

Briefings in bioinformatics
Recent studies have extensively used deep learning algorithms to analyze gene expression to predict disease diagnosis, treatment effectiveness, and survival outcomes. Survival analysis studies on diseases with high mortality rates, such as cancer, ar...

EGPDI: identifying protein-DNA binding sites based on multi-view graph embedding fusion.

Briefings in bioinformatics
Mechanisms of protein-DNA interactions are involved in a wide range of biological activities and processes. Accurately identifying binding sites between proteins and DNA is crucial for analyzing genetic material, exploring protein functions, and desi...

PlasmidHunter: accurate and fast prediction of plasmid sequences using gene content profile and machine learning.

Briefings in bioinformatics
Plasmids are extrachromosomal DNA found in microorganisms. They often carry beneficial genes that help bacteria adapt to harsh conditions. Plasmids are also important tools in genetic engineering, gene therapy, and drug production. However, it can be...

Comprehensive single-cell RNA-seq analysis using deep interpretable generative modeling guided by biological hierarchy knowledge.

Briefings in bioinformatics
Recent advances in microfluidics and sequencing technologies allow researchers to explore cellular heterogeneity at single-cell resolution. In recent years, deep learning frameworks, such as generative models, have brought great changes to the analys...

ifDEEPre: large protein language-based deep learning enables interpretable and fast predictions of enzyme commission numbers.

Briefings in bioinformatics
Accurate understanding of the biological functions of enzymes is vital for various tasks in both pathologies and industrial biotechnology. However, the existing methods are usually not fast enough and lack explanations on the prediction results, whic...

Inference of gene regulatory networks based on directed graph convolutional networks.

Briefings in bioinformatics
Inferring gene regulatory network (GRN) is one of the important challenges in systems biology, and many outstanding computational methods have been proposed; however there remains some challenges especially in real datasets. In this study, we propose...

TP-LMMSG: a peptide prediction graph neural network incorporating flexible amino acid property representation.

Briefings in bioinformatics
Bioactive peptide therapeutics has been a long-standing research topic. Notably, the antimicrobial peptides (AMPs) have been extensively studied for its therapeutic potential. Meanwhile, the demand for annotating other therapeutic peptides, such as a...