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Altitude Sickness

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Plasma cytokine profiling to predict susceptibility to acute mountain sickness.

European cytokine network
Extensive studies have been performed on acute mountain sickness (AMS), but biomarkers predicting AMS are lacking. Presently, the mainstay methods to identify AMS biomarkers include proteomic and genetic methods at high altitudes or in hypoxic simula...

CPHNet: a novel pipeline for anti-HAPE drug screening via deep learning-based Cell Painting scoring.

Respiratory research
BACKGROUND: High altitude pulmonary edema (HAPE) poses a significant medical challenge to individuals ascending rapidly to high altitudes. Hypoxia-induced cellular morphological changes in the alveolar-capillary barrier such as mitochondrial structur...

A machine learning-based severity stratification tool for high altitude pulmonary edema.

BMC medical informatics and decision making
This study aimed to identify key predictors for the severity of High Altitude Pulmonary Edema (HAPE) to assist clinicians in promptly recognizing severely affected patients in the emergency department, thereby reducing associated mortality rates. Mul...