AIMC Topic: Animals

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Breaking the cycle of parasitic diseases with edutainment: The intersection of entertainment and education.

PLoS neglected tropical diseases
Parasitic diseases represent a substantial public health challenge worldwide. Traditional educational strategies have often fallen short in driving sustained behavioral shifts that are nonetheless essential for reducing the burden of these diseases. ...

Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq.

Frontiers in immunology
BACKGROUND: Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophagy in the p...

Easy and Fast Discrimination of Female Sand Flies from Species with Infrared Spectroscopy and Multivariate Analysis.

Analytical chemistry
Accurate identification of sandfly species is critical for controlling and preventing the spread of visceral leishmaniasis, a major public health concern in Latin America. Morphological similarities between female and present a significant challeng...

Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Journal of nanobiotechnology
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies a...

Volumetric atlas of the rat inner ear from microCT and iDISCO+ cleared temporal bones.

PeerJ
BACKGROUND: Volumetric atlases are an invaluable tool in neuroscience and otolaryngology, greatly aiding experiment planning and surgical interventions, as well as the interpretation of experimental and clinical data. The rat is a major animal model ...

Prediction of reproductive and developmental toxicity using an attention and gate augmented graph convolutional network.

Scientific reports
Due to the diverse molecular structures of chemical compounds and their intricate biological pathways of toxicity, predicting their reproductive and developmental toxicity remains a challenge. Traditional Quantitative Structure-Activity Relationship ...

A novel feature fusion and mountain gazelle optimizer based framework for the recognition of jute pests in sustainable agriculture.

Scientific reports
Sustainable agriculture is an approach that involves adopting and developing agricultural practices to increase efficiency and preserve resources, both environmentally and economically. Jute is one of the primary sources of income grown in many count...

Extrachromosomal circular DNA drives dynamic genome plasticity: emerging roles in disease progression and clinical potential.

Theranostics
Extrachromosomal circular DNA (eccDNA) has emerged as a dynamic and versatile genomic element with key roles in physiological regulation and disease pathology. This review synthesizes current knowledge on eccDNA, covering its classification, biogenes...

Novel Computational Approaches in the Discovery and Identification of Bioactive Peptides: A Bioinformatics Perspective.

Journal of agricultural and food chemistry
Bioactive peptides are protein molecules known for their specific biological functions, offering promising applications across various fields including medicine, food, and cosmetics. Traditional approaches to the investigation of bioactive peptides t...

The Role of Hydrogen Sulfide in the Localization and Structural-Functional Organization of p53 Following Traumatic Brain Injury: Development of a YOLO Model for Detection and Quantification of Apoptotic Nuclei.

International journal of molecular sciences
Traumatic brain injury (TBI) triggers a cascade of molecular and cellular disturbances, including apoptosis, inflammation, and destabilization of neuronal connections. The transcription factor p53 plays a pivotal role in regulating cell fate followin...