AIMC Topic: Antigen Presentation

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Unbiased Characterization of Peptide-HLA Class II Interactions Based on Large-Scale Peptide Microarrays; Assessment of the Impact on HLA Class II Ligand and Epitope Prediction.

Frontiers in immunology Aug 5, 2020
Human Leukocyte Antigen class II (HLA-II) molecules present peptides to T lymphocytes and play an important role in adaptive immune responses. Characterizing the binding specificity of single HLA-II molecules has profound impacts for understanding ce...
Humans Machine Learning Epitopes, T-Lymphocyte Protein Binding Databases, Protein HLA Antigens Ligands High-Throughput Screening Assays Protein Array Analysis Binding Sites Protein Interaction Domains and Motifs Histocompatibility Antigens Class II Antigen Presentation CD4 Antigens
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Quantitative Prediction of the Landscape of T Cell Epitope Immunogenicity in Sequence Space.

Frontiers in immunology Apr 16, 2019
Immunodominant T cell epitopes preferentially targeted in multiple individuals are the critical element of successful vaccines and targeted immunotherapies. However, the underlying principles of this "convergence" of adaptive immunity among different...
Humans Machine Learning Computer Simulation T-Lymphocytes Epitopes, T-Lymphocyte Receptors, Antigen, T-Cell Computational Biology Datasets as Topic Adaptive Immunity Thermodynamics Major Histocompatibility Complex Antigen Presentation Immunodominant Epitopes
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Pan-Specific Prediction of Peptide-MHC Class I Complex Stability, a Correlate of T Cell Immunogenicity.

Journal of immunology (Baltimore, Md. : 1950) Jul 8, 2016
Binding of peptides to MHC class I (MHC-I) molecules is the most selective event in the processing and presentation of Ags to CTL, and insights into the mechanisms that govern peptide-MHC-I binding should facilitate our understanding of CTL biology. ...
Humans Neural Networks, Computer Epitopes, T-Lymphocyte Peptides Lymphocyte Activation Histocompatibility Antigens Class I Protein Stability Antigen Presentation
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Leveraging Artificial Intelligence for Neoantigen Prediction.

Cancer research Jul 2, 2025
Neoantigens represent a class of antigens within tumor microenvironments that arise from diverse somatic mutations and aberrations specific to tumorigenesis, holding substantial promise for advancing tumor immunotherapy. However, only a subset of neo...
Humans Artificial Intelligence Tumor Microenvironment Neoplasms Receptors, Antigen, T-Cell Immunotherapy Antigens, Neoplasm Antigen Presentation
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A biomimetic robotic antigen-presenting system for sensitive T cell recognition.

Nature methods May 1, 2024
Humans Animals T-Lymphocytes Robotics Biomimetics Antigen Presentation
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