AIMC Topic: Bacteriophages

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Bacterial Virus Ontology; Coordinating across Databases.

Viruses
Bacterial viruses, also called bacteriophages, display a great genetic diversity and utilize unique processes for infecting and reproducing within a host cell. All these processes were investigated and indexed in the ViralZone knowledge base. To faci...

Endolysin LysSA97 is synergistic with carvacrol in controlling Staphylococcus aureus in foods.

International journal of food microbiology
LysSA97 is an endolysin encoded by the bacteriophage SA97, the genome sequence of which has been recently revealed. LysSA97 has lytic activity against a variety of Staphylococcus strains that cause foodborne illness. In order to improve its potential...

Phage and enzyme therapies in wound infections: From lab to bedside.

Chinese medical journal
Antibiotic-resistant (AR) bacterial wound infections (WIs) impose major burdens on healthcare systems, exacerbated by ineffective therapies and stalled antibiotic development. Phage therapy and phage-derived enzymes have gained traction as potent alt...

A solution to the postantibiotic era: phages as precision medicine.

Current opinion in microbiology
Antibiotic-resistant bacterial infections pose a significant global health challenge. Phage therapy provides a promising alternative to antibiotics that enables the specific targeting of pathogenic bacteria while preserving the healthy microbiome. Re...

[Methodological breakthroughs and challenges in research of soil phage microecology].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Phages, as obligate bacterial and archaeal parasites, constitute a virus group of paramount ecological significance due to their exceptional abundance and genetic diversity. These biological entities serve as critical regulators in Earth's ecosystems...

PharaCon: a new framework for identifying bacteriophages via conditional representation learning.

Bioinformatics (Oxford, England)
MOTIVATION: Identifying bacteriophages (phages) within metagenomic sequences is essential for understanding microbial community dynamics. Transformer-based foundation models have been successfully employed to address various biological challenges. Ho...

Predicting phage-host interactions via feature augmentation and regional graph convolution.

Briefings in bioinformatics
Identifying phage-host interactions (PHIs) is a crucial step in developing phage therapy, which is the promising solution to addressing the issue of antibiotic resistance in superbugs. However, the lifestyle of phages, which strongly depends on their...

DeepPBI-KG: a deep learning method for the prediction of phage-bacteria interactions based on key genes.

Briefings in bioinformatics
Phages, the natural predators of bacteria, were discovered more than 100 years ago. However, increasing antimicrobial resistance rates have revitalized phage research. Methods that are more time-consuming and efficient than wet-laboratory experiments...

DeePhafier: a phage lifestyle classifier using a multilayer self-attention neural network combining protein information.

Briefings in bioinformatics
Bacteriophages are the viruses that infect bacterial cells. They are the most diverse biological entities on earth and play important roles in microbiome. According to the phage lifestyle, phages can be divided into the virulent phages and the temper...

Large-scale genomic survey with deep learning-based method reveals strain-level phage specificity determinants.

GigaScience
BACKGROUND: Phage therapy, reemerging as a promising approach to counter antimicrobial-resistant infections, relies on a comprehensive understanding of the specificity of individual phages. Yet the significant diversity within phage populations prese...