AIMC Topic: Gene Library

Clear Filters Showing 1 to 10 of 39 articles

A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the ventral nerve cord.

eLife Jun 10, 2025
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due t...
Drosophila melanogaster Nerve Net Drosophila Proteins Behavior, Animal Drosophila Optogenetics Gene Library Cell Lineage Animals Transcription Factors Neurons
View on PubMed DOI

Challenges and Prospects of DNA-Encoded Library Data Interpretation.

Chemical reviews Nov 7, 2024
DNA-encoded library (DEL) technology is a powerful platform for the efficient identification of novel chemical matter in the early drug discovery process enabled by parallel screening of vast libraries of encoded small molecules through affinity sele...
Humans Gene Library Machine Learning Drug Discovery DNA Small Molecule Libraries
View on PubMed DOI

Machine learning-guided co-optimization of fitness and diversity facilitates combinatorial library design in enzyme engineering.

Nature communications Jul 29, 2024
The effective design of combinatorial libraries to balance fitness and diversity facilitates the engineering of useful enzyme functions, particularly those that are poorly characterized or unknown in biology. We introduce MODIFY, a machine learning (...
Biocatalysis Directed Molecular Evolution Algorithms Mutation Enzymes Protein Engineering Gene Library Machine Learning
View on PubMed DOI

Automating the Illumina DNA library preparation kit for whole genome sequencing applications on the flowbot ONE liquid handler robot.

Scientific reports Apr 8, 2024
Whole-genome sequencing (WGS) is currently making its transition from research tool into routine (clinical) diagnostic practice. The workflow for WGS includes the highly labor-intensive library preparations (LP), one of the most critical steps in the...
Whole Genome Sequencing High-Throughput Nucleotide Sequencing Gene Library Lipopolysaccharides Humans DNA Robotics Reproducibility of Results Workflow
View on PubMed DOI

DANCE: a deep learning library and benchmark platform for single-cell analysis.

Genome biology Mar 19, 2024
DANCE is the first standard, generic, and extensible benchmark platform for accessing and evaluating computational methods across the spectrum of benchmark datasets for numerous single-cell analysis tasks. Currently, DANCE supports 3 modules and 8 po...
Algorithms Deep Learning Single-Cell Analysis Benchmarking Humans Gene Library
View on PubMed DOI

Machine learning to predict continuous protein properties from binary cell sorting data and map unseen sequence space.

Proceedings of the National Academy of Sciences of the United States of America Mar 7, 2024
Proteins are a diverse class of biomolecules responsible for wide-ranging cellular functions, from catalyzing reactions to recognizing pathogens. The ability to evolve proteins rapidly and inexpensively toward improved properties is a common objectiv...
Protein Engineering Gene Library Machine Learning Proteins Mutation
View on PubMed DOI

AtomVision: A Machine Vision Library for Atomistic Images.

Journal of chemical information and modeling Mar 1, 2023
Computer vision techniques have immense potential for materials design applications. In this work, we introduce an integrated and general-purpose AtomVision library that can be used to generate and curate microscopy image (such as scanning tunneling ...
Gene Library Image Processing, Computer-Assisted Microscopy Neural Networks, Computer Machine Learning
View on PubMed DOI

Machine Learning Informs RNA-Binding Chemical Space.

Angewandte Chemie (International ed. in English) Feb 6, 2023
Small molecule targeting of RNA has emerged as a new frontier in medicinal chemistry, but compared to the protein targeting literature our understanding of chemical matter that binds to RNA is limited. In this study, we reported Repository Of BInders...
Biological Assay RNA Machine Learning Microarray Analysis Gene Library
View on PubMed DOI

PIF - A Java library for finding atomic interactions and extracting geometric features supporting the analysis of protein structures.

Methods (San Diego, Calif.) Jun 18, 2022
Proteins play an essential role in the functioning of living organisms. The enormity of the atomic interactions in proteins is essential in controlling their spatial structures and dynamics. It can also provide scientists with valuable information th...
Artificial Intelligence Gene Library Proteins
View on PubMed DOI

Rewritable two-dimensional DNA-based data storage with machine learning reconstruction.

Nature communications May 27, 2022
DNA-based data storage platforms traditionally encode information only in the nucleotide sequence of the molecule. Here we report on a two-dimensional molecular data storage system that records information in both the sequence and the backbone struct...
Information Storage and Retrieval DNA Machine Learning Gene Library Metadata
View on PubMed DOI
Popular Topics
Recent Journals