AIMC Topic: Biological Products
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NP-Scout: Machine Learning Approach for the Quantification and Visualization of the Natural Product-Likeness of Small Molecules.
Biomolecules
Jan 24, 2019
Natural products (NPs) remain the most prolific resource for the development of smallmolecule drugs. Here we report a new machine learning approach that allows the identification of natural products with high accuracy. The method also generates simil...
Peptide Extract from Exhibits Broad-Spectrum Antibacterial Activity.
BioMed research international
Dec 23, 2018
Increasing reports of infectious diseases worldwide have become a global concern in recent times. Depleted antibiotic pipelines, rapid and complex cases of antimicrobial resistance, and emergence and re-emergence of infectious disease have necessitat...
Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach.
PloS one
Sep 28, 2018
In view of the vast number of natural products with potential antiplasmodial bioactivity and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from previous antiplasmodial bioassays and predict bioactivity of these na...
Inhibition of in vitro trichothecenes production by microalgae phenolic extracts.
Food research international (Ottawa, Ont.)
Jul 5, 2018
There is evidence that microalgae phenolic compounds can inhibit the growth of toxigenic fungi. This study aimed to evaluate the ability of microalgae phenolic extracts to inhibit trichothecene production by Fusarium genus and thereby identify parame...
Extending the DIDEO ontology to include entities from the natural product drug interaction domain of discourse.
Journal of biomedical semantics
May 9, 2018
BACKGROUND: Prompted by the frequency of concomitant use of prescription drugs with natural products, and the lack of knowledge regarding the impact of pharmacokinetic-based natural product-drug interactions (PK-NPDIs), the United States National Cen...
Advances in industrial biopharmaceutical batch process monitoring: Machine-learning methods for small data problems.
Biotechnology and bioengineering
Apr 23, 2018
Biopharmaceutical manufacturing comprises of multiple distinct processing steps that require effective and efficient monitoring of many variables simultaneously in real-time. The state-of-the-art real-time multivariate statistical batch process monit...
A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.
Scientific reports
Feb 28, 2018
AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines....
Specialized oxygenated heterocyclics from Villorita cyprinoides with cyclooxygenase-2 and 5-lipoxygenase inhibitory properties.
Food research international (Ottawa, Ont.)
Dec 28, 2017
Villorita cyprinoides is traditional seafood in the coastal regions of Arabian Sea. Bioactivity-guided purification of ethyl acetate:methanol extract of V. cyprinoides resulted in the identification of two O-spirocyclic ether derivatives (1-2) along ...
Characterization of Polyphenolic Content in the Aquatic Plants Ruppia cirrhosa and Ruppia maritima -A Source of Nutritional Natural Products.
Molecules (Basel, Switzerland)
Dec 22, 2017
Herein, the polyphenolic content in extracts of (Petagna) Grande and L.was fully characterized for the first time. High amounts of the main compound chicoric acid () (≤30.2 ± 4.3 mg/g) were found in both species. In addition, eight flavonoids, nam...
Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging.
Materials science & engineering. C, Materials for biological applications
Nov 28, 2017
Curcumin (Curc) reacts with zinc di‑iodine (ZnI) in 2:1molar ratio in the presence of an excess of a base triethylamine ((CHCH)N) in methanol (CHOH) solution towards the amorphous solid material of formula [ZnI(Curc)] (1). The complex was characteriz...
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