AIMC Topic: Macrolides

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Computational planning of the synthesis of complex natural products.

Nature Oct 13, 2020
Training algorithms to computationally plan multistep organic syntheses has been a challenge for more than 50 years. However, the field has progressed greatly since the development of early programs such as LHASA, for which reaction choices at each s...
Automation Macrolides Indans Lactones Sesquiterpenes Indole Alkaloids Chemistry, Organic Benzylisoquinolines Chemistry Techniques, Synthetic Tetrahydroisoquinolines Artificial Intelligence Software Biological Products Knowledge Bases Reproducibility of Results
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Macrolide combination therapy for patients hospitalised with community-acquired pneumonia? An individualised approach supported by machine learning.

The European respiratory journal Dec 12, 2019
BACKGROUND: The role of macrolide/β-lactam combination therapy in community-acquired pneumonia (CAP) of moderate severity is a matter of debate. Macrolides expand the coverage to atypical pathogens and attenuate pulmonary inflammation, but have been ...
Male Middle Aged Aged, 80 and over Adult Europe Drug Therapy, Combination Propensity Score Severity of Illness Index Treatment Outcome Anti-Bacterial Agents Prospective Studies Hospitalization Aged Female Humans Machine Learning Community-Acquired Infections beta-Lactams Macrolides Pneumonia, Bacterial
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Making Sense of Pharmacovigilance and Drug Adverse Event Reporting: Comparative Similarity Association Analysis Using AI Machine Learning Algorithms in Dogs and Cats.

Topics in companion animal medicine Sep 30, 2019
Drug-associated adverse events cause approximately 30 billion dollars a year of added health care expense, along with negative health outcomes including patient death. This constitutes a major public health concern. The US Food and Drug Administratio...
Cats Macrolides Drug Combinations Algorithms Artificial Intelligence Ivermectin Dogs Animals Machine Learning Pharmacovigilance Drug-Related Side Effects and Adverse Reactions
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Mutations associated with change of susceptibility to lincosamides and/or macrolides in field and laboratory-derived Mycoplasma californicum strains in Japan, and development of a rapid detection method for these mutations.

Veterinary microbiology Dec 21, 2018
Five mutations involved in changing of susceptibility to lincosamides and/or macrolides were investigated in field isolates of Mycoplasma californicum in Japan, and reconfirmed in laboratory-derived mutants. In addition, a quick and easy detection me...
Lincosamides Macrolides Mycoplasma Cattle Milk Mutation Female DNA, Bacterial Nucleic Acid Amplification Techniques Mastitis, Bovine Japan Animals Anti-Bacterial Agents Drug Resistance, Bacterial
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Selection for anthelmintic resistant Teladorsagia circumcincta in pre-weaned lambs by treating their dams with long-acting moxidectin injection.

International journal for parasitology. Drugs and drug resistance Nov 10, 2015
Administration of long-acting anthelmintics to pregnant ewes prior to lambing is a common practice in New Zealand. Today, most of these products contain macrocyclic lactone (ML) actives, which because of their lipophilic nature, are detectable in the...
Drug Resistance Animals, Suckling Trichostrongyloidea Trichostrongyloidiasis Nematode Infections Sheep Diseases Macrolides Milk Animals Anthelmintics Female Lactation Sheep
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