AIMC Topic: Berberine

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Unveiling Berberine analogues as potential inhibitors of Escherichia coli FtsZ through machine learning molecular docking and molecular dynamics approach.

Scientific reports Apr 26, 2025
The bacterial cell division protein FtsZ, a crucial GTPase, plays a vital role in the formation of the contractile Z-ring, which is essential for bacterial cytokinesis. Consequently, inhibiting FtsZ could prevent the formation of proto-filaments and ...
Cytoskeletal Proteins Hydrogen Bonding Escherichia coli Bacterial Proteins Molecular Dynamics Simulation Berberine Machine Learning Anti-Bacterial Agents Molecular Docking Simulation Protein Binding
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Coptidis rhizoma and berberine as anti-cancer drugs: A 10-year updates and future perspectives.

Pharmacological research Apr 19, 2025
Cancer continues to be among the most substantial health challenges globally. Among various natural compounds, berberine, an isoquinoline alkaloid obtained from Coptidis Rhizoma, has garnered considerable attention for its broad-spectrum biological a...
Humans Animals Drugs, Chinese Herbal Neoplasms Berberine Antineoplastic Agents, Phytogenic Coptis chinensis
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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori.

Signal transduction and targeted therapy Jul 8, 2024
Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neural network-based deep learning model, ...
Clarithromycin Helicobacter Infections Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Berberine Omeprazole Helicobacter pylori Amoxicillin Humans Anti-Bacterial Agents Animals Deep Learning
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Effect of Oregon grape root extracts on P-glycoprotein mediated transport in cell lines.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques Jan 18, 2024
This study aims to investigate the potential of Oregon grape root extracts to modulate the activity of P-glycoprotein. We performed H-CsA or H-digoxin transport experiments in the absence or presence of two sources of Oregon grape root extracts (E1...
Digoxin Caco-2 Cells Mahonia Madin Darby Canine Kidney Cells Plant Extracts Plant Roots Berberine Dogs Humans Cyclosporine Biological Transport ATP Binding Cassette Transporter, Subfamily B, Member 1 Animals
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Simultaneous quantification of six indicator compounds in Wen-Qing-Yin by high-performance liquid chromatography-diode array detection.

Journal of food and drug analysis Dec 28, 2018
A simple gradient high-performance liquid chromatography with diode array detection (HPLC-DAD) method was used to simultaneously to analyze characteristics of six indicator compounds in the traditional Chinese medicine (TCM) formulation Wen-Qing-Yin ...
Furaldehyde Flavonoids Chromatography, High Pressure Liquid Coumaric Acids Glucosides Drugs, Chinese Herbal Medicine, Chinese Traditional Iridoids Monoterpenes Berberine
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Development of a highly sensitive and specific ELISA method for the determination of l-corydalmine in SD rats with monoclonal antibody.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Sep 14, 2017
l-Corydalmine (l-CDL) is a potent analgesic constituent of the traditional Chinese medicine, Rhizoma Corydalis. However, the pharmacokinetic process and tissue distribution of l-CDL in vivo are still unknown. Therefore, it is necessary to establish a...
Linear Models Tissue Distribution Berberine Chromatography, High Pressure Liquid Reproducibility of Results Liver Enzyme-Linked Immunosorbent Assay Antibodies, Monoclonal Animals Rats, Sprague-Dawley Limit of Detection Rats Myocardium
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