Small regulatory RNAs (sRNAs) are widespread in bacteria. However, characterizing the targets of sRNA regulation in a way that scales with the increasing number of identified sRNAs has proven challenging. Computational methods offer one means for eff...
International journal of biological macromolecules
Jun 1, 2025
Cervical cancer is one of the leading causes of death among women worldwide. Current treatments are limited by chemoresistance and chemotherapeutic agents' adverse effects, prompting the search for better therapeutic alternatives. Baicalein, a natura...
International journal of biological macromolecules
Jun 1, 2025
DNA methylation is a critical epigenetic modification that plays a central role in gene regulation, cellular differentiation, and the development of various diseases, including cancers. Aberrant methylation patterns have emerged as both biomarkers an...
International journal of biological macromolecules
Jun 1, 2025
The insulin receptor (IR) is a transmembrane protein that controls glucose homeostasis and is highly associated with chronic diseases including cancer and neurological. Traditional experimental methods have provided essential insights into IR structu...
Adverse Drug Reactions (ADRs) during pregnancy pose significant risks to both the mother and the fetus. Conventional approaches to predict ADR are inadequate due to ethical restrictions that prevent performing medication studies in pregnant women, le...
Small nucleolar RNAs (snoRNAs) are increasingly recognized for their critical role in the pathogenesis and characterization of various human diseases. Consequently, the precise identification of snoRNA-disease associations (SDAs) is essential for the...
Ecotoxicology and environmental safety
Jun 1, 2025
Autism Spectrum Disorder (ASD) is a prevalent neurodevelopmental condition influenced by both genetic and environmental factors, including pesticide exposure. This study aims to investigate the pathogenic mechanisms of ASD and identify potential caus...
Computer methods and programs in biomedicine
Jun 1, 2025
BACKGROUND AND OBJECTIVE: Understanding gene-disease relationships is crucial for medical research, drug discovery, clinical diagnosis, and other fields. However, there is currently no high-quality, fine-grained corpus available for training Natural ...
BACKGROUND AND OBJECTIVE: The Gene Ontology (GO) project has been pivotal in providing a structured framework for characterizing genes and annotating them to specific biological concepts. While traditional gene annotation primarily focuses on mapping...
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Jun 1, 2025
BACKGROUND: Diseases caused by pathogenic microorganisms pose a persistent global health challenge. Pathogens exploit host mechanisms through intricate molecular interactions. Understanding these host-pathogen interactions (HPIs), particularly protei...
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