AIMC Topic: Proto-Oncogene Proteins c-pim-1

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Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm.

Frontiers in immunology Dec 11, 2024
BACKGROUND: Abdominal aortic aneurysm (AAA) is a serious life-threatening vascular disease, and its ferroptosis/cuproptosis markers have not yet been characterized. This study was aiming to identify markers associated with ferroptosis/cuproptosis in ...
Humans Machine Learning Algorithms Biomarkers Animals Male Gene Expression Profiling RNA-Seq Single-Cell Gene Expression Analysis Mice Computational Biology Disease Models, Animal Ferroptosis Aortic Aneurysm, Abdominal Proto-Oncogene Proteins c-pim-1
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Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins.

International journal of biological macromolecules Jun 1, 2025
Cervical cancer is one of the leading causes of death among women worldwide. Current treatments are limited by chemoresistance and chemotherapeutic agents' adverse effects, prompting the search for better therapeutic alternatives. Baicalein, a natura...
Humans Machine Learning Female Uterine Cervical Neoplasms Molecular Docking Simulation Protein Binding Computational Biology Cell Proliferation Proto-Oncogene Proteins c-pim-1 Molecular Dynamics Simulation Flavanones Cyclin-Dependent Kinase 2
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