AIMC Topic: Proto-Oncogene Proteins c-pim-1

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Mechanism of triptolide in the treatment of gastric cancer with diabetes through JAK2/STAT3 pathway.

European journal of pharmacology Nov 25, 2025
Univariate and multivariate Cox analyses revealed a correlation between diabetes and the prognosis of gastric cancer patients (p < 0.05). Using bioinformatics, Serine/threonine-protein kinase pim-1 (PIM1) was identified as the core target gene of tri...
Humans Male Middle Aged Female Stomach Neoplasms Glucose STAT3 Transcription Factor Proto-Oncogene Proteins c-pim-1 Epoxy Compounds Phenanthrenes Janus Kinase 2 Diterpenes Signal Transduction Diabetes Mellitus Gene Expression Regulation, Neoplastic Cell Movement Cell Proliferation Apoptosis Cell Line, Tumor
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Integrating transcriptomics, network analysis, and single-cell RNA sequencing to identify and validate key target genes of gynostemma in the treatment of non-alcoholic fatty liver disease.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences Jul 22, 2025
This study explores the therapeutic targets and mechanisms of Gynostemma pentaphyllum in non-alcoholic fatty liver disease (NAFLD). Using network analysis and bioinformatics, we identified target genes of Gynostemma's active metabolites in NAFLD thro...
Gynostemma Non-alcoholic Fatty Liver Disease Gene Regulatory Networks Sequence Analysis, RNA Plant Extracts Proto-Oncogene Proteins c-pim-1 Transcriptome Single-Cell Analysis Gene Expression Profiling Humans
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Integration of bulk/scRNA-seq and multiple machine learning algorithms identifies PIM1 as a biomarker associated with cuproptosis and ferroptosis in abdominal aortic aneurysm.

Frontiers in immunology Dec 11, 2024
BACKGROUND: Abdominal aortic aneurysm (AAA) is a serious life-threatening vascular disease, and its ferroptosis/cuproptosis markers have not yet been characterized. This study was aiming to identify markers associated with ferroptosis/cuproptosis in ...
Single-Cell Gene Expression Analysis Mice RNA-Seq Ferroptosis Aortic Aneurysm, Abdominal Computational Biology Proto-Oncogene Proteins c-pim-1 Biomarkers Disease Models, Animal Male Humans Machine Learning Gene Expression Profiling Animals Algorithms
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Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins.

International journal of biological macromolecules Jun 1, 2025
Cervical cancer is one of the leading causes of death among women worldwide. Current treatments are limited by chemoresistance and chemotherapeutic agents' adverse effects, prompting the search for better therapeutic alternatives. Baicalein, a natura...
Female Uterine Cervical Neoplasms Molecular Docking Simulation Protein Binding Humans Machine Learning Molecular Dynamics Simulation Cyclin-Dependent Kinase 2 Cell Proliferation Flavanones Computational Biology Proto-Oncogene Proteins c-pim-1
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