BACKGROUND: 5-formylcytidine (f5C) is a unique post-transcriptional RNA modification present at the wobble position of mRNAs and tRNAs, that plays a critical role in mitochondrial protein synthesis and is potentially involved in translation regulatio...
With a goal of unveiling mechanisms by which vaccines can provide protection against HIV-1 acquisition, several studies have explored correlates of risk of HIV-1 acquisition in HVTN 505, which was a phase IIb trial conducted to assess the safety and ...
BACKGROUND: Inflammation plays a critical role in ischemic stroke (IS). This study aimed to identify inflammation-related genes and explore potential pharmacological agents for future preclinical validation in IS.
The role of chromatin regulators (CRs) in mediating epigenetic changes during tuberculosis (TB) infection remains poorly understood. This study aimed to determine the efficacy of CRs in diagnosing TB and characterizing its heterogeneity. GSE83456 dat...
ATP, a high-energy phosphate compound also known as adenosine triphosphate, serves as a direct energy source for living organisms. Proteins, composed of amino acids, are fundamental macromolecules and essential building blocks of life. The interactio...
Psoriasis is a systemic immune‑mediated skin disease, typically considered to be incurable. Identification of meaningful biomarkers has been a notable challenge in psoriasis prevention and management. The present study aimed to determine the signatur...
Acute myocardial infarction (AMI) triggered cardiomyocyte senescence and impaired cardiac function. Methylation modifications and related enzymes in patients were also significantly altered, but the association between cellular senescence and demethy...
Precision oncology relies on predictive biomarkers for selecting targeted cancer therapies. Network-based properties of proteins, together with structural features such as intrinsic disorder, are likely to shape their potential as biomarkers. We ther...
BACKGROUND: Intervertebral disc degeneration (IDD) is prevalent in orthopaedics, yet lacks effective treatments. This study seeks to discover potential therapeutic targets for IDD to inform clinical therapies and traditional medicine approaches.
Inferring gene regulatory networks (GRNs) is essential for understanding biological regulation. Although numerous deep learning approaches have been developed for GRN inference, most require large amounts of labeled data. We present Meta-TGLink, a st...
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