IEEE journal of biomedical and health informatics
Mar 6, 2025
Drug repositioning has emerged as a promising strategy for identifying new therapeutic applications for existing drugs. In this study, we present DRGBCN, a novel computational method that integrates heterogeneous information through a deep bilinear a...
IEEE journal of biomedical and health informatics
Mar 6, 2025
Predicting G protein-coupled receptor (GPCR) -ligand binding affinity plays a crucial role in drug development. However, determining GPCR-ligand binding affinities is time-consuming and resource-intensive. Although many studies used data-driven metho...
IEEE journal of biomedical and health informatics
Mar 6, 2025
Cancer is a multifaceted disease that results from co-mutations of multi biological molecules. A promising strategy for cancer therapy involves in exploiting the phenomenon of Synthetic Lethality (SL) by targeting the SL partner of cancer gene. Since...
International journal of biological macromolecules
Mar 5, 2025
Intrinsically disordered proteins (IDPs) or regions (IDRs) are widespread in proteomes, and involved in several important biological processes and implicated in many diseases. Many computational methods for IDR prediction are being developed to decre...
The tumor-homing peptides (THPs) have emerged as one of the attractive resources for targeted cancer therapy, being able to bind and penetrate tumor cells selectively while ignoring adjacent healthy tissues. Therefore, the computational models to pre...
Protein allostery is a fundamental biological regulatory mechanism that allows communication between distant locations within a protein, modifying its function in response to signals. Experimental techniques, such as NMR spectroscopy and cryo-electro...
Breast cancer remains a global health burden, with an increase in deaths related to this particular cancer. Accurately predicting and diagnosing breast cancer is important for treatment development and survival of patients. This study aimed to accura...
The discovery of unique microRNA (miR) patterns and their corresponding genes in sarcoma patients indicates their involvement in cancer development and suggests their potential use in medical management. MiRs were identified from The Cancer Genome At...
BACKGROUND: Acute kidney injury (AKI) after kidney transplantation is one of the main causes of graft loss and poor patient prognosis, and it is important to explore new targets for treating AKI in kidney transplantation.
Understanding the intricacies of genes function within biological systems is paramount for scientific advancement and medical progress. Owing to the evolving landscape of this research and the complexity of biological processes, however, this task pr...
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