AIMC Topic: Computer Simulation

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In Silico tool for predicting, designing and scanning IL-2 inducing peptides.

Scientific reports Jul 16, 2025
Interleukin-2 (IL-2) based immunotherapy has been approved for treating certain types of cancer, as IL-2 plays a crucial role in regulating the immune system. In this study, we developed a method for predicting IL-2-inducing peptides. Our method was ...
Interleukin-2 Machine Learning Computer Simulation Deep Learning Computational Biology Peptides Humans
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Potential diagnostic and therapeutic gene in chronic low back pain through pyroptosis modulation: A silico study based on the dataset analysis.

Scientific reports Jul 16, 2025
Chronic low back pain (cLBP ) is a common condition that affects the quality of life, can be caused by disc degeneration, facet arthropathy, myofascial pain, sacroiliac joint pain, spondyloarthropathies, and nociplastic pain etc. Research suggests th...
Biomarkers Computer Simulation Gene Expression Profiling Humans Pyroptosis Gene Expression Regulation Low Back Pain Gene Regulatory Networks Computational Biology Chronic Pain
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Surgical embodied intelligence for generalized task autonomy in laparoscopic robot-assisted surgery.

Science robotics Jul 16, 2025
Surgical robots capable of autonomously performing various tasks could enhance efficiency and augment human productivity in addressing clinical needs. Although current solutions have automated specific actions within defined contexts, they are challe...
Task Performance and Analysis Computer Simulation Animals Robotic Surgical Procedures Artificial Intelligence Automation Algorithms Humans Laparoscopy
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Machine learning-enabled estimation of cardiac output from peripheral waveforms is independent of blood pressure measurement location in an in silico population.

Scientific reports Jul 15, 2025
Monitoring of cardiac output (CO) is a mainstay of hemodynamic management in the acutely or critically ill patient. Invasive determination of CO using thermodilution, albeit regarded as the gold standard, is cumbersome and bears risks inherent to cat...
Cardiac Output Blood Pressure Determination Blood Pressure Machine Learning Male Humans Neural Networks, Computer Computer Simulation Middle Aged Female
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In silico design of smaller size enzymatic protein by generative artificial intelligence (ProtGPT2).

Journal of bioscience and bioengineering Jul 10, 2025
The construction of small proteins by removing amino acid subsequences that are not involved in function, activity, or structure is crucial for bioprocessing and drug development. Traditional design methods often focus on reconstructing functional mo...
Computer Simulation Sequence Alignment Generative Artificial Intelligence Amino Acid Motifs Models, Molecular Amino Acid Sequence Malate Dehydrogenase Protein Engineering Artificial Intelligence
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In-silico CT simulations of deep learning generated heterogeneous phantoms.

Biomedical physics & engineering express Jul 10, 2025
Current virtual imaging phantoms primarily emphasize geometric accuracy of anatomical structures. However, to enhance realism, it is also important to incorporate intra-organ detail. Because biological tissues are heterogeneous in composition, virtua...
Algorithms Computer Simulation Deep Learning Imaging, Three-Dimensional Tomography, X-Ray Computed Humans Phantoms, Imaging Image Processing, Computer-Assisted Signal-To-Noise Ratio
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Trajectory tracking and obstacle avoidance in dynamic environments using an improved artificial potential field method.

PloS one Jul 10, 2025
Ensuring that a robot employing demonstration learning models can simultaneously achieve accurate trajectory tracking of demonstrated paths and effective avoidance of moving obstacles in dynamic environments remains a critical research challenge. Thi...
Motion Humans Algorithms Models, Theoretical Computer Simulation Robotics
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Prediction of Internal Exposures after Virtual Oral Doses of Disparate Chemicals in Rats and Humans Using Simplified Physiologically Based Pharmacokinetic Models with Generated Input Parameters.

Chemical research in toxicology Jul 8, 2025
Toxicological evaluation of industrial chemicals with a broad range of chemical structures, for example, bioactive food components, toxic food-derived compounds, and drugs, usually involves the estimation of human clearance by allometric extrapolatio...
Models, Biological Humans Administration, Oral Computer Simulation Animals Rats
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Machine learning assisted adjustment boosts efficiency of exact inference in randomized controlled trials.

Scientific reports Jul 8, 2025
In this work, we proposed a novel inferential procedure assisted by machine learning based adjustment for randomized control trials. The method was developed under the Rosenbaum's framework of exact tests in randomized experiments with covariate adju...
Randomized Controlled Trials as Topic Algorithms Humans Machine Learning Computer Simulation
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Simulation of emitter discharge along drip laterals under drip fertigation system using artificial neural network.

PloS one Jul 8, 2025
Simulation of emitter discharge under a drip fertigation system is important for capturing the variation in water and nutrient distribution to crops. This is important for an effective design and irrigation management for agricultural crops. Moreover...
Neural Networks, Computer Computer Simulation Models, Theoretical Crops, Agricultural Agricultural Irrigation
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