AIMC Topic: CTLA-4 Antigen

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Biomarker discovery with quantum neural networks: a case-study in CTLA4-activation pathways.

BMC bioinformatics Apr 12, 2024
BACKGROUND: Biomarker discovery is a challenging task due to the massive search space. Quantum computing and quantum Artificial Intelligence (quantum AI) can be used to address the computational problem of biomarker discovery from genetic data.
Neural Networks, Computer Artificial Intelligence Quantum Theory Computing Methodologies CTLA-4 Antigen
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Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy.

Cancer research Oct 13, 2021
Cancer immunotherapy provides durable clinical benefit in only a small fraction of patients, and identifying these patients is difficult due to a lack of reliable biomarkers for prediction and evaluation of treatment response. Here, we demonstrate th...
Machine Learning Tumor Microenvironment Animals Immune Checkpoint Inhibitors B7-H1 Antigen Mice Immunotherapy Spectrum Analysis, Raman Mice, Inbred BALB C Colonic Neoplasms Tumor Cells, Cultured CTLA-4 Antigen
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Machine learning defined diagnostic criteria for differentiating pituitary metastasis from autoimmune hypophysitis in patients undergoing immune checkpoint blockade therapy.

European journal of cancer (Oxford, England : 1990) Aug 12, 2019
PURPOSE: New-onset pituitary gland lesions are observed in up to 18% of cancer patients undergoing treatment with immune checkpoint blockers (ICB). We aimed to develop and validate an imaging-based decision-making algorithm for use by the clinician t...
Humans Machine Learning Algorithms Neoplasms ROC Curve B7-H1 Antigen Pituitary Neoplasms Diagnosis, Differential Programmed Cell Death 1 Receptor Autoimmune Hypophysitis CTLA-4 Antigen Radioimmunotherapy
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Predicting antibody binders and generating synthetic antibodies using deep learning.

mAbs Jan 1, 2022
The antibody drug field has continually sought improvements to methods for candidate discovery and engineering. Historically, most such methods have been laboratory-based, but informatics methods have recently started to make an impact. Deep learning...
Deep Learning Antibodies Programmed Cell Death 1 Receptor Complementarity Determining Regions CTLA-4 Antigen
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