In the field of neuroscience, epilepsy is a chronic non-communicable brain disease that affects approximately 50 million people worldwide. Electroencephalography (EEG) has become a key tool in detecting and characterizing human neurological diseases ...
While altered pre-mRNA splicing is a frequent mechanism by which genetic variants cause disease, the regulatory architecture of human exons remains poorly understood. Antisense oligonucleotides (AONs) that target pre-mRNA splicing have been approved ...
BACKGROUND AND PURPOSE: Delta biomarkers that reflect changes in tumour burden over time can support personalised follow-up in head and neck cancer. However, their clinical use can be limited by the need for manual image segmentation. This study exte...
Journal of chemical theory and computation
Aug 29, 2025
Development of suitable scoring functions is essential for the prediction of RNA-protein complex structures. Conventional statistical potential-based scoring functions suffered from deficiencies in handling conformational flexibility. The recent appl...
Journal of chemical information and modeling
Aug 29, 2025
Antimicrobial Peptides (AMPs) are a promising strategy to address bacterial resistance, yet only a limited number have advanced to clinical trials. Recent advances in deep learning provide new opportunities for AMP design. Here, we propose an integra...
Cancer imaging : the official publication of the International Cancer Imaging Society
Aug 29, 2025
BACKGROUND: This study aimed to develop a predictive model integrating multi-sequence MRI radiomics, deep learning features, and habitat imaging to forecast pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant therapy...
BACKGROUND: RNA post-transcriptional modifications involve the addition of chemical groups to RNA molecules or alterations to their local structure. These modifications can change RNA base pairing, affect thermal stability, and influence RNA folding,...
Precise and early detection and diagnosis of lung diseases reduce the severity of life risk and further spread of infections in patients. Computer-based image processing techniques utilize magnetic resonance imaging (MRI) as input for computing, dete...
Opinion mining is more challenging than it was before because of all the user-generated material on social media. People use Twitter (X) to gather opinions on products, advancements, and laws. Sentiment Analysis (SA) examines people's thoughts, feeli...
AI has propelled the potential for moving toward personalized health and early prediction of diseases. Unfortunately, a significant limitation of many of these deep learning models is that they are not interpretable, restricting their clinical utilit...
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