AIMC Topic: DNA, Catalytic

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SequenceCraft: machine learning-based resource for exploratory analysis of RNA-cleaving deoxyribozymes.

BMC bioinformatics Jan 6, 2025
BACKGROUND: Deoxyribozymes or DNAzymes represent artificial short DNA sequences bearing many catalytic properties. In particular, DNAzymes able to cleave RNA sequences have a huge potential in gene therapy and sequence-specific analytic detection of ...
Machine Learning Computational Biology RNA DNA, Catalytic
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Bacteriophage-Activated DNAzyme Hydrogels Combined with Machine Learning Enable Point-of-Use Colorimetric Detection of Escherichia coli.

Advanced materials (Deerfield Beach, Fla.) Nov 26, 2024
Developing cost-effective, consumer-accessible platforms for point-of-use environmental and clinical pathogen testing is a priority, to reduce reliance on laborious, time-consuming culturing approaches. Unfortunately, a system offering ultrasensitive...
Humans Machine Learning Point-of-Care Systems Colorimetry Biosensing Techniques Escherichia coli Gold Metal Nanoparticles Hydrogels DNA, Catalytic Bacteriophages
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Double-integrated mimic enzymes for the visual screening of Microcystin-LR: Copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme.

Analytica chimica acta Dec 15, 2018
Recently, mimic enzymes have obtained particular interest by their high activity, stability, and biocompatibility. In this work, by coupling copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme to form a double-integrated mimic enzyme, a visual, ...
Biosensing Techniques Copper Hemin Immunoassay Marine Toxins Microcystins Nanostructures Base Sequence Biomimetic Materials DNA, Catalytic G-Quadruplexes Hydroxides
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Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence.

Analytica chimica acta Dec 27, 2016
The analysis of DNA methylation and MTase activities is very important in the early clinical diagnosis of cancer, on purposes of providing insights into the mechanism of gene repression and developing novel drugs of treating methylation-related disea...
Fluorescence DNA Methylation Nucleic Acid Amplification Techniques DNA Modification Methylases DNA Probes Nucleic Acid Conformation DNA, Catalytic
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Identification and Classification of Functional Split G-Quadruplexes Using Machine Learning-Guided Activity Screening.

ACS applied bio materials Jun 16, 2025
Split G-quadruplexes are considered excellent tools for biosensing and diagnostics, but splitting G-quadruplexes may often lead to a loss of function, limiting their effectiveness. This study aims to identify and classify functional split G-quadruple...
Machine Learning Particle Size Materials Testing Biocompatible Materials DNA, Catalytic G-Quadruplexes
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