AIMC Topic: DNA

Clear Filters Showing 41 to 50 of 457 articles

Challenges and Prospects of DNA-Encoded Library Data Interpretation.

Chemical reviews Nov 7, 2024
DNA-encoded library (DEL) technology is a powerful platform for the efficient identification of novel chemical matter in the early drug discovery process enabled by parallel screening of vast libraries of encoded small molecules through affinity sele...
Small Molecule Libraries Gene Library Drug Discovery DNA Humans Machine Learning
View on PubMed DOI

Effect of graphene electrode functionalization on machine learning-aided single nucleotide classification.

Nanoscale Nov 7, 2024
Solid-state nanogap-based DNA sequencing with a quantum tunneling approach has emerged as a promising avenue due to its potential to deliver swift and precise sequencing outcomes. Nevertheless, despite significant progress, experimentally achieving s...
DNA Electrodes Machine Learning Sequence Analysis, DNA Nucleotides Graphite
View on PubMed DOI

A General DNA-Like Hybrid Symbiosis Framework: An EEG Cognitive Recognition Method.

IEEE journal of biomedical and health informatics Nov 6, 2024
In electroencephalogram (EEG) cognitive recognition research, the combined use of artificial neural networks (ANNs) and spiking neural networks (SNNs) plays an important role to realize different categories of recognition tasks. However, most of the ...
Humans Neural Networks, Computer Signal Processing, Computer-Assisted Pattern Recognition, Automated DNA Electroencephalography Algorithms Cognition
View on PubMed DOI

GeoNet enables the accurate prediction of protein-ligand binding sites through interpretable geometric deep learning.

Structure (London, England : 1993) Nov 1, 2024
The identification of protein binding residues is essential for understanding their functions in vivo. However, it remains a computational challenge to accurately identify binding sites due to the lack of known residue binding patterns. Local residue...
Deep Learning RNA Protein Binding Ligands Computational Biology DNA Binding Sites Proteins Models, Molecular
View on PubMed DOI

An Integrated Multi-Model Framework Utilizing Convolutional Neural Networks Coupled with Feature Extraction for Identification of 4mC Sites in DNA Sequences.

Computers in biology and medicine Oct 28, 2024
N4-methylcytosine (4mC) is a chemical modification that occurs on one of the four nucleotide bases in DNA and plays a vital role in DNA expression, repair, and replication. It also actively participates in the regulation of cell differentiation and g...
Humans Cytosine Neural Networks, Computer Sequence Analysis, DNA DNA
View on PubMed DOI

Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy.

Journal of medicinal chemistry Oct 23, 2024
DNA-encoded library (DEL) technology is an effective method for small molecule drug discovery, enabling high-throughput screening against target proteins. While DEL screening produces extensive data, it can reveal complex patterns not easily recogniz...
Cell Cycle Proteins Small Molecule Libraries E1A-Associated p300 Protein Bromodomain Containing Proteins Humans DNA Machine Learning High-Throughput Screening Assays Drug Discovery Transcription Factors
View on PubMed DOI

Artificial Intelligence-Enhanced Analysis of Genomic DNA Visualized with Nanoparticle-Tagged Peptides under Electron Microscopy.

Small (Weinheim an der Bergstrasse, Germany) Oct 9, 2024
DNA visualization has advanced across multiple microscopy platforms, albeit with limited progress in the identification of novel staining agents for electron microscopy (EM), notwithstanding its ability to furnish a broad magnification range and high...
Artificial Intelligence Gold Metal Nanoparticles Peptides Microscopy, Electron DNA
View on PubMed DOI

Machine learning based predictive analysis of DNA cleavage induced by diverse nanomaterials.

Scientific reports Sep 20, 2024
DNA cleavage by nanomaterials has the potential to be utilized as an innovative tool for gene editing. Numerous nanomaterials exhibiting DNA cleavage properties have been identified and cataloged. Yet, the exploitation of property data through data-d...
Machine Learning Algorithms Neural Networks, Computer Nanostructures Support Vector Machine DNA Cleavage DNA
View on PubMed DOI

Predicting DNA Reactions with a Quantum Chemistry-Based Deep Learning Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Sep 19, 2024
In this study, a deep learning model based on quantum chemistry is introduced to enhance the accuracy and efficiency of predicting DNA reaction parameters. By integrating quantum chemical calculations with self-designed descriptor matrices, the model...
Quantum Theory Deep Learning DNA
View on PubMed DOI

Developing a Machine Learning 'Smart' Polymerase Chain Reaction Thermocycler Part 2: Putting the Theoretical Framework into Practice.

Genes Sep 12, 2024
The introduction of PCR into forensic science and the rapid increases in the sensitivity, specificity and discrimination power of DNA profiling that followed have been fundamental in shaping the field of forensic biology. Despite these developments, ...
Forensic Genetics DNA DNA Fingerprinting Humans Machine Learning Polymerase Chain Reaction
View on PubMed DOI
Popular Topics
Recent Journals