International journal of pharmaceutics
Dec 22, 2025
Patches represent a significant dosage form within transdermal drug delivery systems. In the quality control of transdermal patches, thickness not only affects the drug loading per unit area and drug release behavior but also is associated with patie...
International journal of pharmaceutics
Dec 5, 2025
Mathematical modeling is becoming increasingly important in the pharmaceutical industry. It supports the Quality by Design framework by aiding process understanding and examining the impact of critical material and process parameters on the critical ...
The purpose of this work was to formulate and characterize pH-sensitive, surfactant-based nanomicelles for the targeted delivery of Oxaliplatin to breast cancer cells. A secondary aim was to utilize machine learning (ML) models to interpolate and dis...
In cancer combination therapy, micro-robot systems that integrate multiple therapeutic functions have emerged as a key direction for overcoming the limitations of traditional treatments. This study proposes a magnetic thermosensitive hydrogel capsule...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
Existing oral drug delivery modalities often fall short in medical emergencies due to the absence of readily deployable, internalized drug storage and delivery mechanisms that combine long-term standby with rapid activation. To address this challenge...
Journal of controlled release : official journal of the Controlled Release Society
Oct 25, 2025
Ionic liquids (ILs) have emerged as a transformative platform in drug delivery, overcoming key limitations of conventional systems such as poor drug solubility, low bioavailability, and inadequate targeting. Through rational cation-anion engineering,...
International journal of pharmaceutics
Oct 23, 2025
Understanding the molecular mechanisms of drug coamorphization remains a key challenge in solid-state pharmaceutics. This study presents a molecular level strategy for designing drug-drug coamorphous systems (CAMs) of apremilast (APR) and aceclofenac...
The aim of this study was to develop and evaluate a liposomal formulation of fentanyl to improve its analgesic efficacy and safety profile in anesthesia, using artificial intelligence (AI) techniques to characterize and optimize the formulation. The ...
International journal of pharmaceutics
Oct 13, 2025
The disintegration behaviour of pharmaceutical tablets is a critical quality attribute influencing drug release, yet predicting it from formulation and processing parameters remains challenging due to complex underlying mechanisms. This work presents...
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