AIMC Topic: Drug Resistance, Bacterial
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Synergistic effect of horizontal transfer of antibiotic resistance genes between bacteria exposed to microplastics and per/polyfluoroalkyl substances: An explanation from theoretical methods.
Journal of hazardous materials
Apr 8, 2025
Microplastics (MPs) and per/polyfluoroalkyl substances (PFASs), as emerging pollutants widely present in aquatic environments, pose a significant threat to human health through the horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs)....
Febrile neutropenia management in high-risk neutropenic patients: a narrative review on antibiotic prophylaxis and empirical treatment.
Expert review of anti-infective therapy
Apr 4, 2025
INTRODUCTION: Although febrile neutropenia (FN) remains a major cause of morbidity and mortality in patients with hematologic malignancies and hematopoietic stem cell transplant (HSCT) recipients, the increasing prevalence of antimicrobial resistance...
Quantitative prediction of disinfectant tolerance in Listeria monocytogenes using whole genome sequencing and machine learning.
Scientific reports
Mar 26, 2025
Listeria monocytogenes is a potentially severe disease-causing bacteria mainly transmitted through food. This pathogen is of great concern for public health and the food industry in particular. Many countries have implemented thorough regulations, an...
Assessment for antibiotic resistance in : A practical and interpretable machine learning model based on genome-wide genetic variation.
Virulence
Mar 21, 2025
() antibiotic resistance poses a global health threat. Accurate identification of antibiotic resistant strains is essential for the control of infection. In the present study, our goal is to leverage the whole-genome data of to develop practical an...
ListPred: A predictive ML tool for virulence potential and disinfectant tolerance in Listeria monocytogenes.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Mar 18, 2025
Despite current surveillance and sanitation strategies, foodborne pathogens continue to threaten the food industry and public health. Whole genome sequencing (WGS) has reached an unprecedented resolution to analyse and compare pathogenic bacterial is...
SERS-based approaches in the investigation of bacterial metabolism, antibiotic resistance, and species identification.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Mar 13, 2025
Surface-enhanced Raman scattering (SERS) is an inelastic scattering phenomenon that occurs when photons interact with substances, providing detailed molecular structure information. It exhibits various advantages including high sensitivity, specifici...
DRAMMA: a multifaceted machine learning approach for novel antimicrobial resistance gene detection in metagenomic data.
Microbiome
Mar 7, 2025
BACKGROUND: Antibiotics are essential for medical procedures, food security, and public health. However, ill-advised usage leads to increased pathogen resistance to antimicrobial substances, posing a threat of fatal infections and limiting the benefi...
Targeting Bacterial RNA Polymerase: Harnessing Simulations and Machine Learning to Design Inhibitors for Drug-Resistant Pathogens.
Biochemistry
Feb 27, 2025
The increase in antimicrobial resistance presents a major challenge in treating bacterial infections, underscoring the need for innovative drug discovery approaches and novel inhibitors. Bacterial RNA polymerase (RNAP) has emerged as a crucial target...
Label-free rapid antimicrobial susceptibility testing with machine-learning based dynamic holographic laser speckle imaging.
Biosensors & bioelectronics
Feb 25, 2025
Antimicrobial resistance (AMR) presents a significant global challenge, creating an urgent need for rapid and sensitive antimicrobial susceptibility testing (AST) methods to guide timely treatment decisions. Traditional AST techniques, such as broth ...
Machine learning for predicting antimicrobial resistance in critical and high-priority pathogens: A systematic review considering antimicrobial susceptibility tests in real-world healthcare settings.
PloS one
Feb 25, 2025
BACKGROUND: Antimicrobial resistance (AMR) poses a worldwide health threat; quick and accurate identification of AMR enhances patient outcomes and reduces inappropriate antibiotic usage. The objective of this systematic review is to evaluate the effi...
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