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Drug Resistance, Bacterial

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Using genomic data and machine learning to predict antibiotic resistance: A tutorial paper.

PLoS computational biology
Antibiotic resistance is a global public health concern. Bacteria have evolved resistance to most antibiotics, which means that for any given bacterial infection, the bacteria may be resistant to one or several antibiotics. It has been suggested that...

Machine learning and clinician predictions of antibiotic resistance in Enterobacterales bloodstream infections.

The Journal of infection
BACKGROUND: Patients with Gram-negative bloodstream infections are at risk of serious adverse outcomes without active treatment, but identifying who has antimicrobial resistance (AMR) to target empirical treatment is challenging.

A novel approach to antimicrobial resistance: Machine learning predictions for carbapenem-resistant Klebsiella in intensive care units.

International journal of medical informatics
This study was conducted at Kocaeli University Hospital in Turkey and aimed to predict carbapenem-resistant Klebsiella pneumoniae infection in intensive care units using the Extreme Gradient Boosting (XGBoost) algorithm, a form of artificial intellig...

Artificial intelligence-driven quantification of antibiotic-resistant Bacteria in food by color-encoded multiplex hydrogel digital LAMP.

Food chemistry
Antibiotic-resistant bacteria pose considerable risks to global health, particularly through transmission in the food chain. Herein, we developed the artificial intelligence-driven quantification of antibiotic-resistant bacteria in food using a color...

Integrating Machine Learning with MALDI-TOF Mass Spectrometry for Rapid and Accurate Antimicrobial Resistance Detection in Clinical Pathogens.

International journal of molecular sciences
Antimicrobial resistance (AMR) is one of the most pressing public health challenges of the 21st century. This study aims to evaluate the efficacy of mass spectral data generated by VITEK MS instruments for predicting antibiotic resistance in , , and ...

ARGai 1.0: A GAN augmented in silico approach for identifying resistant genes and strains in E. coli using vision transformer.

Computational biology and chemistry
The emergence of infectious disease and antibiotic resistance in bacteria like Escherichia coli (E. coli) shows the necessity for novel computational techniques for identifying essential genes that contribute to resistance. The task of identifying re...

Phenotypic antibiotic resistance prediction using antibiotic resistance genes and machine learning models in Mannheimia haemolytica.

Veterinary microbiology
Mannheimia haemolytica is one of the most common causative agents of bovine respiratory disease (BRD); however, antibiotic resistance in this species is increasing, making treatment more difficult. Integrative-conjugative elements (ICE), a subset of ...

Measuring water pollution effects on antimicrobial resistance through explainable artificial intelligence.

Environmental pollution (Barking, Essex : 1987)
Antimicrobial resistance refers to the ability of pathogens to develop resistance to drugs designed to eliminate them, making the infections they cause more difficult to treat and increasing the likelihood of disease diffusion and mortality. As such,...

Reviewing on AI-Designed Antibiotic Targeting Drug-Resistant Superbugs by Emphasizing Mechanisms of Action.

Drug development research
The emergence of drug-resistant bacteria, often referred to as "superbugs," poses a profound and escalating challenge to global health systems, surpassing the capabilities of traditional antibiotic discovery methods. As resistance mechanisms evolve r...

End-To-End Deep Learning Explains Antimicrobial Resistance in Peak-Picking-Free MALDI-MS Data.

Analytical chemistry
Mass spectrometry is used to determine infectious microbial species in thousands of clinical laboratories across the world. The vast amount of data allows modern data analysis methods that harvest more information and potentially answer new questions...