AIMC Topic: Drug Screening Assays, Antitumor

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Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model.

Journal of enzyme inhibition and medicinal chemistry Dec 1, 2020
Cyclin-dependent kinase 2 (CDK2) is the family of Ser/Thr protein kinases that has emerged as a highly selective with low toxic cancer therapy target. A multistage virtual screening method combined by SVM, protein-ligand interaction fingerprints (PLI...
A549 Cells Molecular Structure Drug Screening Assays, Antitumor Structure-Activity Relationship Protein Kinase Inhibitors Cyclin-Dependent Kinase 2 Drug Evaluation, Preclinical HCT116 Cells Antineoplastic Agents Cell Proliferation Support Vector Machine Dose-Response Relationship, Drug Humans Molecular Docking Simulation
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Volatile constituents and in vitro activity of Syzygium aromaticum flower buds (clove) against human cancer cell lines.

Pakistan journal of pharmaceutical sciences Nov 1, 2020
The methanolic extract (SA-EXT) of Syzygium aromaticum flower buds and its fractions tested against three human cancer cell lines viz uterine cervix (HeLa), breast (MCF-7) and lung NCI (H-460) using sulforhodamine-B assay. The ethyl acetate soluble s...
Eugenol Flowers Gas Chromatography-Mass Spectrometry HeLa Cells Syzygium Volatile Organic Compounds Drug Screening Assays, Antitumor Cell Line, Tumor Humans MCF-7 Cells Antineoplastic Agents, Phytogenic Methanol Acetates
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Assessing the Anti-cancer Therapeutic Mechanism of a Herbal Combination for Breast Cancer on System-level by a Network Pharmacological Approach.

Anticancer research Sep 1, 2020
BACKGROUND/AIM: Accumulating evidence has shown therapeutic effects of herbals on breast cancer, a commonly diagnosed malignancy in women worldwide. However, their underlying mechanisms remain unclear. We aimed to explore the mode of action of a rece...
Systems Biology Medicine, Chinese Traditional Cell Line, Tumor Computational Biology Drugs, Chinese Herbal Workflow Antineoplastic Agents, Phytogenic Drug Screening Assays, Antitumor Humans Neural Networks, Computer Female Breast Neoplasms Technology, Pharmaceutical Astragalus propinquus
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The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology.

Oncotarget Feb 14, 2017
Recent advances in deep learning and specifically in generative adversarial networks have demonstrated surprising results in generating new images and videos upon request even using natural language as input. In this paper we present the first applic...
K562 Cells Drug Therapy MCF-7 Cells High-Throughput Screening Assays Reproducibility of Results Neural Networks, Computer Antineoplastic Agents Machine Learning Humans Cell Line, Tumor Drug Screening Assays, Antitumor
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Robotic printing and drug testing of 384-well tumor spheroids.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Aug 1, 2015
A major impediment to anti-cancer drug development is the lack of a reliable and inexpensive tumor model to test the efficacy of candidate compounds. This need has emerged due to the insufficiency of widely-used monolayer cultures to predict drug eff...
Equipment Design Polymers Doxorubicin High-Throughput Screening Assays Drug Screening Assays, Antitumor Robotics Antineoplastic Agents Humans Triple Negative Breast Neoplasms Female Spheroids, Cellular
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