Small (Weinheim an der Bergstrasse, Germany)
Mar 21, 2025
Cytochrome P450 3A4 (CYP3A4) is a key mediator in xenobiotic metabolism and drug-drug interactions (DDI), developing orally active fluorogenic substrates for sensing and imaging of a target enzyme in biological systems remains challenging. Here, an a...
Journal of chemical information and modeling
Mar 20, 2025
The search for functional fluorescent organic materials can significantly benefit from the rapid and accurate predictions of photophysical properties. However, screening large numbers of potential fluorophore molecules in different solvents faces lim...
BACKGROUND: Fluorescence imaging agents have been benefiting tremendously from tailor-made aggregation-induced emission (AIE) luminogens, owing to their high on-off ratio, large signal contrast, low background noise as well as the resistance to photo...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Feb 4, 2025
Computer vision based on instance segmentation deep learning models offers great potential for automating many visual inspection tasks, such as the detection of contaminating grains in bulk oats, a nutrient rich grain which is well-tolerated by peopl...
Understanding molecular dynamics at the nanoscale remains challenging due to limitations in the temporal resolution of current imaging techniques. Deep learning integrated with Single-Molecule Localization Microscopy (SMLM) offers opportunities to pr...
Langmuir : the ACS journal of surfaces and colloids
Jan 11, 2025
Warfarin (WAR), an effective oral anticoagulant, is of utmost importance in treating many diseases. Despite its significance, rapid and precise discrimination of WAR remains a formidable challenge, especially facing its structural analogs of metaboli...
Pathogenic bacteria are the source of many serious health problems, such as foodborne diseases and hospital infections. Timely and accurate detection of these pathogens is of vital significance for disease prevention, control of epidemic spread, and ...
Optical filtering is an indispensable part of fluorescence microscopy for selectively highlighting molecules labeled with a specific fluorophore and suppressing background noise. However, the utilization of optical filtering sets increases the comple...
Journal of colloid and interface science
Nov 17, 2024
In this study, a high-throughput point-of-care testing (HT-POCT) system for detecting serum iron was developed using a hydrophobic deep eutectic solvent (HDES) fluorescence detection platform. This machine learning-assisted portable platform enables ...
Precise navigation within intricate biological systems is pivotal for comprehending cellular functions and diagnosing diseases. Fluorescent molecular probes, designed to target specific biological molecules, are indispensable tools for this endeavor....
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