AIMC Topic: G-Quadruplexes

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Sensitive fluorescent detection of DNA methyltransferase using nicking endonuclease-mediated multiple primers-like rolling circle amplification.

Biosensors & bioelectronics Dec 30, 2016
Sensitive and reliable detection of DNA methyltransferase (MTase) is of great significance for both early tumor diagnosis and therapy. In this study, a simple, label-free and sensitive DNA MTase-sensing method was developed on the basis of a nicking ...
Humans DNA Primers Biosensing Techniques Nucleic Acid Amplification Techniques MCF-7 Cells DNA Spectrometry, Fluorescence HeLa Cells HEK293 Cells DNA (Cytosine-5-)-Methyltransferase 1 Enzyme Assays G-Quadruplexes DNA-Cytosine Methylases DNA (Cytosine-5-)-Methyltransferases Endonucleases
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Identification and Classification of Functional Split G-Quadruplexes Using Machine Learning-Guided Activity Screening.

ACS applied bio materials Jun 16, 2025
Split G-quadruplexes are considered excellent tools for biosensing and diagnostics, but splitting G-quadruplexes may often lead to a loss of function, limiting their effectiveness. This study aims to identify and classify functional split G-quadruple...
Machine Learning Particle Size Materials Testing Biocompatible Materials DNA, Catalytic G-Quadruplexes
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Peptidic Compound as DNA Binding Agent: Fragment-based Design, Machine Learning, Molecular Modeling, Synthesis, and DNA Binding Evaluation.

Protein and peptide letters Jan 1, 2024
BACKGROUND: Cancer remains a global burden, with increasing mortality rates. Current cancer treatments involve controlling the transcription of malignant DNA genes, either directly or indirectly. DNA exhibits various structural forms, including the G...
Humans Machine Learning Computer Simulation Peptides Molecular Docking Simulation Drug Design Antineoplastic Agents Protein Binding DNA Molecular Dynamics Simulation G-Quadruplexes Binding Sites
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