International journal of molecular sciences
Jan 18, 2023
Aberrant miRNA expression has been associated with a large number of human diseases. Therefore, targeting miRNAs to regulate their expression levels has become an important therapy against diseases that stem from the dysfunction of pathways regulated...
Cross-species comparative analyses of single-cell RNA sequencing (scRNA-seq) data allow us to explore, at single-cell resolution, the origins of the cellular diversity and evolutionary mechanisms that shape cellular form and function. Cell-type assig...
Investigating network behavior from host-pathogen interactions is challenging. Here, we present the deep-learning-based protocol to construct an immune-related gene network and list the genes involved in the defense response of host to specific bioti...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2022
Regulatory module mining methods divide genes into multiple gene subgroups and explore potential biological mechanisms from omics data. By transforming gene expression profile data into gene co-expression network, we transform the task of gene module...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2022
Approximate Bayesian Computation is widely used in systems biology for inferring parameters in stochastic gene regulatory network models. Its performance hinges critically on the ability to summarize high-dimensional system responses such as time ser...
IEEE transactions on neural networks and learning systems
Oct 5, 2022
Design is an inseparable part of most scientific and engineering tasks, including real and simulation-based experimental design processes and parameter/hyperparameter tuning/optimization. Several model-based experimental design techniques have been d...
Computational and mathematical methods in medicine
Sep 23, 2022
Acute, chronic myocarditis as myocardial localized or diffuse inflammation lesions is usually involving cardiac function in patients with severe adverse outcomes such as heart failure, sudden death, and no unified, but its pathogenesis clinical is ma...
Proceedings of the National Academy of Sciences of the United States of America
Jun 22, 2022
The high-dimensional character of most biological systems presents genuine challenges for modeling and prediction. Here we propose a neural network-based approach for dimensionality reduction and analysis of biological gene expression data, using, as...
IEEE/ACM transactions on computational biology and bioinformatics
Jun 3, 2022
This article is concerned with the problem of finite-time H state estimation for switched genetic regulatory networks with randomly occurring uncertainties. The persistent dwell-time switching rule, as a more versatile class of switching rules, is co...
In recent years, drug sensitivity prediction has garnered a great deal of attention due to the growing interest in precision medicine. Several computational methods have been developed for drug sensitivity prediction and the identification of related...
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