AIMC Topic: Genetic Therapy
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Analysis on key parameters in subretinal injection facilitating a predictable and automated robot-assisted treatment in gene therapy.
The international journal of medical robotics + computer assisted surgery : MRCAS
Aug 16, 2023
BACKGROUND: Subretinal injection (SRI) has become an important surgical method for treating vitreoretinal diseases. Nevertheless, the optimisation of bleb formation in SRI, for the attainment of desired therapeutic outcomes, still requires further in...
Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD).
ACS applied materials & interfaces
Jul 21, 2023
Gene therapy has emerged as a significant advancement in medicine in recent years. However, the development of effective gene delivery vectors, particularly polymer vectors, remains a significant challenge. Limited understanding of the internal struc...
Overcoming Immunological Challenges Limiting Capsid-Mediated Gene Therapy With Machine Learning.
Frontiers in immunology
Apr 27, 2021
A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, mu...
Machine learning based CRISPR gRNA design for therapeutic exon skipping.
PLoS computational biology
Jan 8, 2021
Restoring gene function by the induced skipping of deleterious exons has been shown to be effective for treating genetic disorders. However, many of the clinically successful therapies for exon skipping are transient oligonucleotide-based treatments ...
Next-generation drug repurposing using human genetics and network biology.
Current opinion in pharmacology
Jan 22, 2020
Drug repurposing has attracted increased attention, especially in the context of drug discovery rates that remain too low despite a recent wave of approvals for biological therapeutics (e.g. gene therapy). These new biological entities-based treatmen...
Improving the Rate of Translation of Tissue Engineering Products.
Advanced healthcare materials
Aug 6, 2019
Over 100 000 research articles and 9000 patents have been published on tissue engineering (TE) in the past 20 years. Yet, very few TE products have made their way to the market during the same period. Experts have proposed a variety of strategies to ...
Low-Invasive Cell Injection based on Rotational Microrobot.
Advanced biosystems
Apr 1, 2019
The advancement of cell injections has created a need for accurate, efficient, and low-invasive injections. However, the conventional approaches to reduce cell damage during penetration, mainly optimization of micropipette tips and vision-based autom...
Back to the future - The integration of big data with machine learning is re-establishing the importance of predictive correlations in ovarian cancer diagnostics and therapeutics.
Gynecologic oncology
Mar 21, 2018
Current and Emerging Precision Therapies for Developmental and Epileptic Encephalopathies.
Pediatric neurology
Jul 1, 2025
Developmental and epileptic encephalopathies (DEEs) are severe neurological disorders characterized by childhood-onset seizures and significant developmental impairments. Seizures are often refractory to treatment with traditional antiseizure medicat...
Revolution of AAV in Drug Discovery: From Delivery System to Clinical Application.
Journal of medical virology
Jun 1, 2025
Adeno-associated virus (AAV) is a non-enveloped DNA virus infecting a wide variety of species, tissues, and cell types, which is recognized as a safe and effective method for delivering therapeutic transgenes. AAV vector is the most popular viral gen...
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