AIMC Topic: Gliosis

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Deep Learning-Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure.

Toxicologic pathology Sep 20, 2022
As regulators of homeostasis, astrocytes undergo morphological changes after injury to limit the insult in central nervous system (CNS). Trimethyltin (TMT) is a known neurotoxicant that induces reactive astrogliosis in rat CNS. To evaluate the degree...
Animals Deep Learning Rats Astrocytes Glial Fibrillary Acidic Protein Hippocampus Gliosis Trimethyltin Compounds
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Astrocyte regional heterogeneity revealed through machine learning-based glial neuroanatomical assays.

The Journal of comparative neurology Mar 8, 2021
Evaluation of reactive astrogliosis by neuroanatomical assays represents a common experimental outcome for neuroanatomists. The literature demonstrates several conflicting results as to the accuracy of such measures. We posited that the diverging res...
Machine Learning Animals Image Processing, Computer-Assisted Mice Microscopy, Confocal Astrocytes Gliosis Fluorescent Antibody Technique
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Comparative study on the effects of cigarette smoke exposure, ethanol consumption and association: Behavioral parameters, apoptosis, glial fibrillary acid protein and S100β immunoreactivity in different regions of the rat hippocampus.

Alcohol (Fayetteville, N.Y.) Aug 23, 2018
Exposure to cigarette smoke and ethanol are proposed to trigger neurotoxicity, apoptosis, and to impair neuronal signaling. However, it is little known how the combination of both might trigger astrogliosis and the morphological changes capable of af...
Animals Male Rats, Wistar Rats Ethanol Apoptosis Cigarette Smoking Glial Fibrillary Acidic Protein Hippocampus Alcohol Drinking Gliosis Inhalation Exposure S100 Calcium Binding Protein beta Subunit Tobacco Smoke Pollution
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