AIMC Topic: Homologous Recombination

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HRProfiler Detects Homologous Recombination Deficiency in Breast and Ovarian Cancers Using Whole-Genome and Whole-Exome Sequencing Data.

Cancer research Jul 2, 2025
UNLABELLED: Breast and ovarian cancers harboring homologous recombination deficiency (HRD) are sensitive to PARP inhibitors and platinum chemotherapy. Conventionally, detecting HRD involves screening for defects in BRCA1, BRCA2, and other relevant ge...
Humans Machine Learning Retrospective Studies Female Breast Neoplasms Ovarian Neoplasms Mutation Whole Genome Sequencing Exome Sequencing Poly(ADP-ribose) Polymerase Inhibitors Homologous Recombination
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Screening of gastric cancer diagnostic biomarkers in the homologous recombination signaling pathway and assessment of their clinical and radiomic correlations.

Cancer medicine Aug 1, 2024
BACKGROUND: Homologous recombination plays a vital role in the occurrence and drug resistance of gastric cancer. This study aimed to screen new gastric cancer diagnostic biomarkers in the homologous recombination pathway and then used radiomic featur...
Humans Machine Learning Tomography, X-Ray Computed Female Aged Stomach Neoplasms Radiomics Biomarkers, Tumor Male Middle Aged Gene Expression Regulation, Neoplastic Signal Transduction Neoplasm Staging DNA-Binding Proteins Homologous Recombination
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