AIMC Topic: Host-Pathogen Interactions
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An improved method for predicting interactions between virus and human proteins.
Journal of bioinformatics and computational biology
Jul 10, 2016
The interaction of virus proteins with host proteins plays a key role in viral infection and consequent pathogenesis. Many computational methods have been proposed to predict protein-protein interactions (PPIs), but most of the computational methods ...
HPIDB 2.0: a curated database for host-pathogen interactions.
Database : the journal of biological databases and curation
Jul 3, 2016
Identification and analysis of host-pathogen interactions (HPI) is essential to study infectious diseases. However, HPI data are sparse in existing molecular interaction databases, especially for agricultural host-pathogen systems. Therefore, resourc...
Representing virus-host interactions and other multi-organism processes in the Gene Ontology.
BMC microbiology
Jul 28, 2015
BACKGROUND: The Gene Ontology project is a collaborative effort to provide descriptions of gene products in a consistent and computable language, and in a species-independent manner. The Gene Ontology is designed to be applicable to all organisms but...
Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells.
Scientific reports
Jul 16, 2015
The microbiome's underlying dynamics play an important role in regulating the behavior and health of its host. In order to explore the details of these interactions, we created an in silico model of a living microbiome, engineered with synthetic biol...
A tuberculosis ontology for host systems biology.
Tuberculosis (Edinburgh, Scotland)
Jun 30, 2015
A major hurdle facing tuberculosis (TB) investigators who want to utilize a rapidly growing body of data from both systems biology approaches and omics technologies is the lack of a standard vocabulary for data annotation and reporting. Lacking a mea...
Predicting host-pathogen interactions with machine learning algorithms: A scoping review.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Jun 1, 2025
BACKGROUND: Diseases caused by pathogenic microorganisms pose a persistent global health challenge. Pathogens exploit host mechanisms through intricate molecular interactions. Understanding these host-pathogen interactions (HPIs), particularly protei...
Predicting phage-host interactions via feature augmentation and regional graph convolution.
Briefings in bioinformatics
Nov 22, 2024
Identifying phage-host interactions (PHIs) is a crucial step in developing phage therapy, which is the promising solution to addressing the issue of antibiotic resistance in superbugs. However, the lifestyle of phages, which strongly depends on their...
deepHPI: a comprehensive deep learning platform for accurate prediction and visualization of host-pathogen protein-protein interactions.
Briefings in bioinformatics
May 13, 2022
Host-pathogen protein interactions (HPPIs) play vital roles in many biological processes and are directly involved in infectious diseases. With the outbreak of more frequent pandemics in the last couple of decades, such as the recent outburst of Covi...
The reactome pathway knowledgebase 2022.
Nucleic acids research
Jan 7, 2022
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired dise...
Fighting COVID-19 with Artificial Intelligence.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2022
The development of vaccines for the treatment of COVID-19 is paving the way for new hope. Despite this, the risk of the virus mutating into a vaccine-resistant variant still persists. As a result, the demand of efficacious drugs to treat COVID-19 is ...
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