AIMC Topic: Hydrocodone

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Predicting inadequate postoperative pain management in depressed patients: A machine learning approach.

PloS one Feb 6, 2019
Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSRIs), inhibits CYP-2D6 activity...
Humans Machine Learning Electronic Health Records Female Aged Adult Male Middle Aged Depression Natural Language Processing Pain, Postoperative Models, Biological Pain Management Postoperative Period Drug Prescriptions Antidepressive Agents Hydrocodone Selective Serotonin Reuptake Inhibitors
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Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.

Pain medicine (Malden, Mass.) Dec 14, 2015
OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the intranasal abuse potential ...
Humans Female Young Adult Adult Male Middle Aged Double-Blind Method Analgesics, Opioid Opioid-Related Disorders Cross-Over Studies Powders Illicit Drugs Drug Administration Schedule Delayed-Action Preparations Administration, Intranasal Hydrocodone
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