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Hydrocodone

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Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users.

Pain medicine (Malden, Mass.) 26814240
OBJECTIVES: A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER® [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the intranasal abuse potential ...
Administration, Intranasal Adult Analgesics, Opioid Cross-Over Studies Delayed-Action Preparations Double-Blind Method Drug Administration Schedule Female Humans Hydrocodone Illicit Drugs Male Middle Aged Opioid-Related Disorders Powders Young Adult
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Predicting inadequate postoperative pain management in depressed patients: A machine learning approach.

PloS one 30726237
Widely-prescribed prodrug opioids (e.g., hydrocodone) require conversion by liver enzyme CYP-2D6 to exert their analgesic effects. The most commonly prescribed antidepressant, selective serotonin reuptake inhibitors (SSRIs), inhibits CYP-2D6 activity...
Adult Aged Antidepressive Agents Depression Drug Prescriptions Electronic Health Records Female Humans Hydrocodone Machine Learning Male Middle Aged Models, Biological Natural Language Processing Pain Management Pain, Postoperative Postoperative Period Selective Serotonin Reuptake Inhibitors
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