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In Situ Hybridization

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Deep convolutional neural networks for annotating gene expression patterns in the mouse brain.

BMC bioinformatics 25948335
BACKGROUND: Profiling gene expression in brain structures at various spatial and temporal scales is essential to understanding how genes regulate the development of brain structures. The Allen Developing Mouse Brain Atlas provides high-resolution 3-D...
Animals Brain Gene Expression Profiling Gene Expression Regulation, Developmental Image Processing, Computer-Assisted In Situ Hybridization Mice Molecular Sequence Annotation Neural Networks, Computer Pattern Recognition, Automated
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Deep Neural Networks for In Situ Hybridization Grid Completion and Clustering.

IEEE/ACM transactions on computational biology and bioinformatics 30106689
Transcriptome in brain plays a crucial role in understanding the cortical organization and the development of brain structure and function. Two challenges, incomplete data and high dimensionality of transcriptome, remain unsolved. Here, we present a ...
Animals Atlases as Topic Brain Cluster Analysis Computational Biology Gene Expression Profiling Image Processing, Computer-Assisted In Situ Hybridization Mice Neural Networks, Computer Transcriptome
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A deep learning based method for large-scale classification, registration, and clustering of in-situ hybridization experiments in the mouse olfactory bulb.

Journal of neuroscience methods 30529409
BACKGROUND: The Allen Mouse Brain Atlas allows study of the brain's molecular anatomy at cellular scale, for thousands genes. To fully leverage this resource, one must register histological images of brain tissue - a task made challenging by the brai...
Animals Atlases as Topic Cluster Analysis Deep Learning Image Processing, Computer-Assisted In Situ Hybridization Mice Olfactory Bulb Transcriptome
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Evaluation of deep convolutional neural networks for in situ hybridization gene expression image representation.

PloS one 35073334
High resolution in situ hybridization (ISH) images of the brain capture spatial gene expression at cellular resolution. These spatial profiles are key to understanding brain organization at the molecular level. Previously, manual qualitative scoring ...
Adult Brain Case-Control Studies Datasets as Topic Female Humans Image Interpretation, Computer-Assisted In Situ Hybridization Machine Learning Male Middle Aged Neural Networks, Computer Schizophrenia Transcriptome Young Adult
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