AIMC Topic: Ion Channels

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ICEPO: the ion channel electrophysiology ontology.

Database : the journal of biological databases and curation Apr 7, 2016
Ion channels are transmembrane proteins that selectively allow ions to flow across the plasma membrane and play key roles in diverse biological processes. A multitude of diseases, called channelopathies, such as epilepsies, muscle paralysis, pain syn...
Ion Channel Gating Humans Mutation Models, Biological Databases as Topic Electrophysiology Molecular Sequence Annotation Gene Ontology Ion Channels
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SPECTRUS: A Dimensionality Reduction Approach for Identifying Dynamical Domains in Protein Complexes from Limited Structural Datasets.

Structure (London, England : 1993) Jul 9, 2015
Identifying dynamical, quasi-rigid domains in proteins provides a powerful means for characterizing functionally oriented structural changes via a parsimonious set of degrees of freedom. In fact, the relative displacements of few dynamical domains us...
Adenylate Kinase Escherichia coli Tobacco mosaic satellite virus Models, Molecular Internet Capsid Software Multifactor Dimensionality Reduction Thermodynamics Ion Channels Protein Structure, Tertiary
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Briefing in application of machine learning methods in ion channel prediction.

TheScientificWorldJournal Apr 16, 2015
In cells, ion channels are one of the most important classes of membrane proteins which allow inorganic ions to move across the membrane. A wide range of biological processes are involved and regulated by the opening and closing of ion channels. Ion ...
Computational Biology Algorithms Support Vector Machine Humans Computer Simulation Databases, Genetic Reproducibility of Results Models, Biological Machine Learning Ion Channels
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Application of stochastic automata networks for creation of continuous time Markov chain models of voltage gating of gap junction channels.

BioMed research international Feb 1, 2015
The primary goal of this work was to study advantages of numerical methods used for the creation of continuous time Markov chain models (CTMC) of voltage gating of gap junction (GJ) channels composed of connexin protein. This task was accomplished by...
Models, Theoretical Markov Chains Ion Channels Humans Neural Networks, Computer Connexins Gap Junctions
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Machine Learning Methods for the Analysis of the Patch-Clamp Signals.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2024
Patch-clamp technique provides a unique possibility to record the ion channels' activity. This method enables tracking the changes in their functional states at controlled conditions on a real-time scale. Kinetic parameters evaluated for the patch-cl...
Ion Channels Humans Ion Channel Gating Machine Learning Patch-Clamp Techniques Animals
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Computational Ion Channel Research: from the Application of Artificial Intelligence to Molecular Dynamics Simulations.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Mar 3, 2021
Although ion channels are crucial in many physiological processes and constitute an important class of drug targets, much is still unclear about their function and possible malfunctions that lead to diseases. In recent years, computational methods ha...
Humans Artificial Intelligence Protein Conformation, alpha-Helical Ligands Protein Conformation, beta-Strand Quantitative Structure-Activity Relationship Membrane Transport Modulators Binding Sites Ion Channel Gating Ion Channels Structural Homology, Protein Protein Interaction Domains and Motifs Protein Binding Models, Molecular Software Molecular Dynamics Simulation Animals
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Chaos versus noise as drivers of multistability in neural networks.

Chaos (Woodbury, N.Y.) Oct 1, 2018
The multistable behavior of neural networks is actively being studied as a landmark of ongoing cerebral activity, reported in both functional Magnetic Resonance Imaging (fMRI) and electro- or magnetoencephalography recordings. This consists of a cont...
Nonlinear Dynamics Synapses Stochastic Processes Models, Neurological Data Collection Neural Conduction Oscillometry Ion Channels Magnetoencephalography Neural Networks, Computer Algorithms Humans Temperature Magnetic Resonance Imaging Cluster Analysis
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Some Remarks on Prediction of Drug-Target Interaction with Network Models.

Current topics in medicinal chemistry Jan 1, 2017
System-level understanding of the relationships between drugs and targets is very important for enhancing drug research, especially for drug function repositioning. The experimental methods used to determine drug-target interactions are usually time-...
Molecular Targeted Therapy Ion Channels Pharmaceutical Preparations Ligands Humans Neural Networks, Computer Algorithms Molecular Docking Simulation Receptors, G-Protein-Coupled
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