AIMC Topic: Knowledge Bases

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Using a Clinical Knowledge Base to Assess Comorbidity Interrelatedness Among Patients with Multiple Chronic Conditions.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Decision support tools increasingly integrate clinical knowledge such as medication indications and contraindications with electronic health record (EHR) data to support clinical care and patient safety. The availability of this encoded information a...

tcTKB: an integrated cardiovascular toxicity knowledge base for targeted cancer drugs.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Targeted cancer drugs are often associated with unexpectedly high cardiovascular (CV) adverse events. Systematic approaches to studying CV events associated with targeted anticancer drugs have high potential for elucidating the complex pathways under...

Drug-drug Interaction Discovery Using Abstraction Networks for "National Drug File - Reference Terminology" Chemical Ingredients.

AMIA ... Annual Symposium proceedings. AMIA Symposium
The National Drug File - Reference Terminology (NDF-RT) is a large and complex drug terminology. NDF-RT provides important information about clinical drugs, e.g., their chemical ingredients, mechanisms of action, dosage form and physiological effects...

Scotland's knowledge network: a progress report on Knowledge into Action.

Scottish medical journal
Launched in 2012, Knowledge into Action is the national knowledge management strategy for the health and social care workforce in Scotland. It is transforming the role of the national digital knowledge service--NHS Education for Scotlands' Knowledge ...

Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus.

eLife
Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron proper...

SORTA: a system for ontology-based re-coding and technical annotation of biomedical phenotype data.

Database : the journal of biological databases and curation
There is an urgent need to standardize the semantics of biomedical data values, such as phenotypes, to enable comparative and integrative analyses. However, it is unlikely that all studies will use the same data collection protocols. As a result, ret...

Connecting proteins with drug-like compounds: Open source drug discovery workflows with BindingDB and KNIME.

Database : the journal of biological databases and curation
Today's large, public databases of protein-small molecule interaction data are creating important new opportunities for data mining and integration. At the same time, new graphical user interface-based workflow tools offer facile alternatives to cust...

APL: An angle probability list to improve knowledge-based metaheuristics for the three-dimensional protein structure prediction.

Computational biology and chemistry
Tertiary protein structure prediction is one of the most challenging problems in structural bioinformatics. Despite the advances in algorithm development and computational strategies, predicting the folded structure of a protein only from its amino a...

Expert system supporting an early prediction of the bronchopulmonary dysplasia.

Computers in biology and medicine
This work presents a decision support system which uses machine learning to support early prediction of bronchopulmonary dysplasia (BPD) for extremely premature infants after their first week of life. For that purpose a knowledge database was created...