AIMC Topic: Alanine Transaminase

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Markers of body fat, the mediating role of alanine aminotransferase, and their association with the risk of metabolic dysfunction-associated steatotic liver disease.

European journal of pediatrics
Metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity correlates with metabolic dysfunction, yet interactions between anthropometrics, liver enzymes, and risk of MASLD remain unclear. This study included 219 childr...

Multi-modal predictive modeling of schizophrenia severity: Leveraging liver function indicators and cognitive scores with random forest and SVM.

Psychiatry research. Neuroimaging
Schizophrenia is a complex neuropsychiatric disorder with cognitive deficits and systemic physiological disturbances, including emerging links to hepatic dysfunction via the gut-liver-brain axis. Despite growing evidence, the integration of liver fun...

A machine learning-based framework for predicting metabolic syndrome using serum liver function tests and high-sensitivity C-reactive protein.

Scientific reports
Metabolic Syndrome (MetS) comprises a clustering of conditions that significantly increase the risk of heart disease, stroke, and diabetes. Timely detection and intervention are crucial in preventing severe health outcomes. In this study, we implemen...

A miniaturized liver function detection system with machine learning enhancing strategy.

Biosensors & bioelectronics
Serum alanine aminotransferase (ALT) is one of the most sensitive indicators of liver function and is crucial in diagnosing acute liver injury (ALI). However, its widespread clinical application is limited due to expensive equipment, detection delays...

Integrating Machine Learning and Follow-Up Variables to Improve Early Detection of Hepatocellular Carcinoma in Tyrosinemia Type 1: A Multicenter Study.

International journal of molecular sciences
Hepatocellular carcinoma (HCC) is a major complication of tyrosinemia type 1 (HT-1), an inborn error of metabolism affecting tyrosine catabolism. The risk of HCC is higher in late diagnoses despite treatment. Alpha-fetoprotein (AFP) is widely used to...

Machine learning model to predict the adherence of tuberculosis patients experiencing increased levels of liver enzymes in Indonesia.

PloS one
Indonesia is still the second-highest tuberculosis burden country in the world. The antituberculosis adverse drug reaction and adherence may influence the success of treatment. The objective of this study is to define the model for predicting the adh...

A machine learning model for predicting abnormal liver function induced by a Chinese herbal medicine preparation (Zhengqing Fengtongning) in patients with rheumatoid arthritis based on real-world study.

Journal of integrative medicine
OBJECTIVE: Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects the small joints of the whole body and degrades the patients' quality of life. Zhengqing Fengtongning (ZF) is a traditional Chinese medicine preparation used to treat ...

Severity prediction markers in dengue: a prospective cohort study using machine learning approach.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
BACKGROUND: Dengue virus causes illnesses with or without warning indicators for severe complications. There are no clear prognostic signs linked to the disease outcomes.

A potential new way to facilitate HCV elimination: The prediction of viremia in anti-HCV seropositive patients using machine learning algorithms.

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
BACKGROUND AND STUDY AIMS: The present study was undertaken to design a new machine learning (ML) model that can predict the presence of viremia in hepatitis C virus (HCV) antibody (anti-HCV) seropositive cases.